73111-14-5

Upstream product

• 97-30-3 methyl-alpha-D-glucopyranoside 
• 100-39-0 benzyl bromide 
• 7465-44-3 methyl 6-bromo-6-deoxy-α-D-glucopyranoside 
• 53008-65-4 methyl 2,3,4-tri-O-benzyl-D-glucopyranoside 
• 3162-96-7 methyl 4,6-O-benzylidene-α-D-glucopyranoside 
• 7177-79-9 methyl 2,3-di-O-benzyl-4,6-O-benzylidene-α-D-glucopyranoside 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 1079205-73-4 C₃₇H₅₂O₆Si 

Downstream Products

• 73111-18-9 (3aR)-4c,5t,6c-tris-benzyloxy-1-methyl-(3ar,6ac)-hexahydro-cyclopenta[c]isoxazole 
• 73111-58-7 2,3,4-tri-O-benzyl-5,6-dideoxy-D-xylo-hex-5-enose 
• 134784-86-4 (3R,4S,5S)-3,4,5-tribenzyloxydodeca-1,11-dien-6-ol 
• 134784-87-5 (3R,4S,5S)-3,4,5-tribenzyloxydodeca-1,11-dien-6-one 
• 134820-81-8 (2R,3S,4R,5R,6R)-1-Benzyl-2-(5-chloro-6-hydroxy-hexyl)-6-hydroxymethyl-piperidine-3,4,5-triol 
• 134784-88-6 (3R,4S,5S,6S)-6-amino-(N-benzyl)-3,4,5-tribenzyloxydodeca-1,11-diene 
• 134930-15-7 (3R,4S,5S,6R)-6-amino-(N-benzyl)-3,4,5-tribenzyloxydodeca-1,11-diene 
• 134820-80-7 ((2R,3R,4R,5S,6R)-1-Benzyl-3,4,5-tris-benzyloxy-6-hex-5-enyl-piperidin-2-yl)-methanol 
• 134784-91-1 [(2R,3R,4R,5S,6R)-1-Benzyl-3,4,5-tris-benzyloxy-6-(4-oxiranyl-butyl)-1-oxy-piperidin-2-yl]-methanol 
• 134784-89-7 6-((2R,3S,4R,5R,6R)-1-Benzyl-3,4,5-tris-benzyloxy-6-hydroxymethyl-1-oxy-piperidin-2-yl)-2-chloro-hexan-1-ol 
• 19139-89-0 (2R,3R,4S,5R,6S)-2-Azidomethyl-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran 
• 1461750-25-3 (3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-methyltetrahydro-2H-pyran-2-one 
• 73174-45-5 (2S,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-2-methoxy-6-methyltetrahydro-2H-pyran 
• 73111-47-4 (3aR,3'aR)-4c,5t,6c,4'c',5't',6'c'-hexakis-benzyloxy-(3ar,6ac,3'ar',6'ac')-dodecahydro-1,1'-methanediyl-bis-cyclopenta[c]isoxazole 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

In this work, aiming at finding a novel, potent, and selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor with good pharmacokinetic profiles for the treatment of diabetes, we focus on modifying the sugar moiety of SGLT2 inhibitors, which dominates the binding with glucose binding site of hSGLT, via removing the C-6 hydroxy group to adjust the physicochemical properties and target-recognition manners of SGLT2 inhibitors. In addition, tofogliflozin containing a special O-spiroketal C-arylglucoside scaffold, displayed good efficacy and bioavailability both in animals and in humans. Therefore, a series of 6-deoxy O-spiroketal C-arylglucosides as novel SGLT2 inhibitors were designed, synthesized, and evaluated in this work. The structure-activity relationship (SAR) research on this novel series and a comprehensive in vitro and in vivo biological evaluation afforded compound 39 with high in vitro hSGLT2 inhibitory activity (IC50 = 4.5 nM), good pharmacokinetic profiles, and more remarkable efficacy in C57BL/6J mice and Sprague-Dawley rats than marketed drug tofogliflozin.

C,O-SPIRO ARYL GLYCOSIDE COMPOUNDS, PREPARATION THEREFOR AND USE THEREOF

The present invention provides C, O-spiro aryl glycoside compounds, preparation therefor and use thereof. Specifically provided are the compounds represented by the formula (I), wherein the definitions of each group are described in the specification. The

Conversion of D-Glucose to Cyclitol with Hydroxymethyl Substituent via Intramolecular Silyl Nitronate Cycloaddition Reaction: Application to Total Synthesis of (+)-Cyclophellitol

(Matrix presented). A diastereoisomeric mixture of 1-nitro-6-heptene-2,3,4, 5-tetraol derivative (A) was prepared by Henry reaction between D-glucose-based aldehyde and nitromethane. Only the (2S)-isomer of A led to cyclitol (B) via nitronate-olefin cyclo

Halogenation of carbohydrates by triphenylphosphine complex reagents in highly concentrated solution under microwave activation or conventional heating

Halogenation of carbohydrates with triphenylphosphine and carbon tetrachloride, hexachloroethane or 1,2-dibromotetrachloroethane was shown to be very efficient in highly concentrated solutions of nonpolar solvents such as toluene or 1,2-dichloroethane, wi

Solvent-free benzylation of polyols by phase-transfer catalysis or supported reagent methods

Solvent-free techniques were successfully and efficiently applied under mild conditions to the perbenzylation of methyl α-D-glucopyranoside and methyl 6-bromo(and 6-chloro)-6-deoxy-α-D-glucopyranoside, and to the selective monobenzylation of diethyl (R,R)