73148-14-8

Basic information

• Product Name: 2(1H)-QUINOXALINONE, 1-ETHYL-3-METHYL-
• Synonyms: 2(1H)-QUINOXALINONE, 1-ETHYL-3-METHYL-;1-ethyl-3-methylquinoxalin-2(1H)-one
• CAS NO: 73148-14-8
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.229
• Mol File: 73148-14-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 316.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.15±0.1 g/cm3(Predicted)
• PKA: 0.21±0.70(Predicted)
• CAS DataBase Reference: 2(1H)-QUINOXALINONE, 1-ETHYL-3-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-QUINOXALINONE, 1-ETHYL-3-METHYL-(73148-14-8)
• EPA Substance Registry System: 2(1H)-QUINOXALINONE, 1-ETHYL-3-METHYL-(73148-14-8)

Safety Data

• Hazardous Substances Data: 73148-14-8(Hazardous Substances Data)

Usage

Heterocyclic compound

2(1H)-Quinoxalinone, 1-ethyl-3-methylis a compound that contains a ring structure with at least one heteroatom, which is an atom other than carbon, such as nitrogen or oxygen.

Derivative of quinoxalinone

2(1H)-Quinoxalinone, 1-ethyl-3-methylis a modified version of the compound quinoxalinone, which has a similar structure but lacks the ethyl and methyl groups.

Ethyl and methyl groups

2(1H)-Quinoxalinone, 1-ethyl-3-methylhas an ethyl (C2H5) and a methyl (CH3) group attached to specific positions on the ring structure, which can affect its chemical properties and potential pharmaceutical applications.

Pharmaceutical applications

2(1H)-Quinoxalinone, 1-ethyl-3-methylhas potential applications in the pharmaceutical industry, including as a sedative and anxiolytic agent to reduce anxiety and promote relaxation.

Anti-tumor and anti-inflammatory properties

2(1H)-Quinoxalinone, 1-ethyl-3-methylhas been studied for its potential to inhibit tumor growth and reduce inflammation, which could lead to the development of new cancer and anti-inflammatory treatments.

Precursor for the synthesis of other bioactive compounds

2(1H)-Quinoxalinone, 1-ethyl-3-methylcan be used as a starting material for the synthesis of other compounds with potential biological activity, making it a valuable building block in medicinal chemistry.

Interesting target for further research

The chemical structure and properties of 2(1H)-Quinoxalinone, 1-ethyl-3-methylmake it an interesting target for further research and development in the field of medicinal chemistry, as it may lead to the discovery of new drugs and therapies.

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 63536-46-9 N-ethyl quinoxalin-2(1H)-one 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 1779-49-3 Methyltriphenylphosphonium bromide 
• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 
• 95-54-5 1,2-diamino-benzene 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 75-91-2 tert.-butylhydroperoxide 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 23838-73-5 N-ethyl-benzene-1,2-diamine 
• 127-17-3 2-oxo-propionic acid 

Downstream Products

• 1186528-13-1 1-ethyl-3-{[(4-methylphenyl)sulfonyl]methyl}quinoxalin-2(1H)-one 
• 1266609-20-4 1-ethyl-3-methyl-3',5'-diphenyl-1H,3'H-spiro[quinoxaline-2,2'-[1,3,4]thiadiazole] 

Relevant articles and documents

Visible-light-induced decarboxylative alkylation of quinoxalin-2(1H)-ones with phenyliodine(III) dicarboxylates by cerium photocatalysis

Despite advances in the photoredox catalysis using organic dyes or expensive Ir and Ru complexes, the discovery and employment of photocatalysts based on alternative and abundant metal salts remain highly necessary. Herein, the visible-light-induced decarboxylative alkylation of quinoxalin-2(1H)-ones with phenyliodine(III) dicarboxylate has been accomplished using inexpensive and catalytic amount of CeCl3 as the photocatalyst. The novel protocol has advantages of mild conditions, high yields and good substrate scope. Control experiments indicate that a radical mechanism is responsible for the present transformation.

Alkylation of quinoxalin-2(1H)-ones using phosphonium ylides as alkylating reagents

A practical and efficient methodology for the construction of 3-alkylquinoxalinones through base promoted direct alkylation of quinoxalin-2(1H)-ones with phosphonium ylides as alkylating reagents under metal- and oxidant-free conditions was developed. Various 3-alkylquinoxalin-2(1H)-ones were easily obtained in good to excellent yields. Tentative mechanistic studies suggest that this reaction is likely to involve a nucleophilic addition-elimination process.

Peroxide-mediated site-specific C-H methylation of imidazo[1,2-: A] pyridines and quinoxalin-2(1 H)-ones under metal-free conditions

An effective approach to realize the direct methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones with peroxides under metal-free conditions is described. In this protocol, peroxides serve as both the radical initiator and methyl source. Methylated imidazopyridines and quinoxalin-2(1H)-ones were smoothly synthesized in moderate to good yields. A free radical reaction mechanism was proposed to describe the methylation process.