63536-46-9

Basic information

• Product Name: 2(1H)-Quinoxalinone,1-ethyl-(9CI)
• Synonyms: 2(1H)-Quinoxalinone,1-ethyl-(9CI)
• CAS NO: 63536-46-9
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Product Categories: QUINOLINONE
• Mol File: 63536-46-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 64-65 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 309.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• PKA: -0.39±0.70(Predicted)
• CAS DataBase Reference: 2(1H)-Quinoxalinone,1-ethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Quinoxalinone,1-ethyl-(9CI)(63536-46-9)
• EPA Substance Registry System: 2(1H)-Quinoxalinone,1-ethyl-(9CI)(63536-46-9)

Safety Data

• Hazardous Substances Data: 63536-46-9(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Structure

Contains a quinoxalinone ring with an ethyl substituent

Usage

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Usage

Building block in the production of other chemical compounds (e.g. pesticides and dyes)

Potential

Biological activities

Applications

Medicinal chemistry and drug discovery

Note

Specific properties and uses may vary depending on the context and the specific research or industrial application.

Upstream product

• 1196-57-2 quinoxalin-2⁽¹⁾-one 
• 75-03-6 ethyl iodide 
• 1196-57-2 2-hydroxyquinoxaline 
• 74-96-4 ethyl bromide 
• 14003-34-0 3-methyl-2-oxo-1,2-dihydroquinoxaline 
• 75-00-3 chloroethane 
• 59564-59-9 1,2,3,4-tetrahydroquinoxalin-2-one 
• 5428-05-7 n-(2-nitrophenyl)glycine ethyl ester 
• 1493-27-2 ortho-nitrofluorobenzene 
• 95-54-5 1,2-diamino-benzene 
• 64-17-5 ethanol 
• 36818-07-2 ethyl 3-oxo-4H-quinoxaline-2-carboxylate 

Downstream Products

• 88392-55-6 1-ethyl-3-phenylquinoxalin-2(1H)-one 
• 1186527-86-5 3-(4-chlorophenyl)-1-ethylquinoxalin-2(1H)-one 
• 586348-21-2 ataquimast 
• 73148-14-8 1-ethyl-3-methylquinoxalin-2(1H)-one 

Relevant articles and documents

Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones

Herein, we report a practical electro-reductive protocol for the direct C–H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.

Method for catalytically preparing 3-sulfur substituted quinoxalinone derivative

The invention relates to a method for catalytically preparing a 3-sulfur substituted quinoxalinone derivative. The method comprises the following steps of: firstly preparing a 3-(thiophenyl) quinoxaline-2 (1H)-ketone derivative, then adding the 3-(thiophenyl) quinoxaline-2 (1H)-ketone derivative, disulfide, an oxidizing agent and a catalyst into a reaction container, adding a solvent, reacting under the light irradiation of a blue lamp, and after the reaction is completed, filtering, extracting, concentrating, separating and purifying to obtain the 3-sulfur substituted quinoxalinone derivative. According to the invention, the problem that a traditional catalyst needs high-temperature reaction is solved, disulfide is used as a raw material, the problem that foul thiophenol and thiol substances are used as raw materials traditionally is solved, and a green and efficient synthesis method is used to promote industrialization of a reaction system; and meanwhile, quinoxalinone compounds with different substituent groups are also efficiently expanded.

Metal-Free Direct Oxidative C?N Bond Coupling of Quinoxalin-2(1H)-ones with Azoles under Mild Conditions

Direct C3?H amination of quinoxalin-2(1H)-ones with azoles under mild conditions promoted by PIFA has been achieved in good yield in a very fast manner. Mechanistic study revealed that the reaction proceeds through a radical process. In addition, this method could be applied to gram-scale reaction.