7315-69-7

Upstream product

• 7315-68-6 3-methyl-4-phenylbutanoic acid 
• 451-40-1 phenyl benzyl ketone 
• 6052-53-5 3-Methyl-4-phenyl-3-butensaeure 
• 7315-67-5 3-methyl-4-oxo-4-phenylbutanoic acid 
• 7315-66-4 diethyl 2-(1-oxo-1-phenylpropan-2-yl)malonate 
• 93-55-0 1-phenyl-propan-1-one 

Downstream Products

• 7315-70-0 6-Benzyl-2-methyl-heptanon-⁽⁴⁾ 
• 14944-23-1 3-methyl-1-tetralone 
• 138816-37-2 trans-4-methyl-5-phenylpyrrolidin-2-one 
• 7315-71-1 6-Benzyl-2-methyl-heptanol-⁽⁴⁾ 

Relevant academic research and scientific papers

Decarboxylative Borylation of mCPBA-Activated Aliphatic Acids

A decarboxylative borylation of aliphatic acids for the synthesis of a variety of alkylboronates has been developed by mixing m-chloroperoxybenzoic acid (mCPBA)-activated fatty acids with bis(catecholato)diboron in N,N-dimethylformamide (DMF) at room temperature. A radical chain process is involved in the reaction which initiates from the B-B bond homolysis followed by the radical transfer from the boron atom to the carbon atom with subsequent decarboxylation and borylation.

Synthetic Utility of N-Benzoyloxyamides as an Alternative Precursor of Acylnitrenoids for γ-Lactam Formation

Described herein is the development of a new entry of acylnitrenoid precursors for γ-lactam synthesis via an intramolecular C-H amidation reaction. Upon Ir catalysis, N-benzoyloxyamides serve as efficient substrates to afford 5-membered amides. Mechanistic studies revealed that the generation of a putative Ir-carbonylnitrenoid via N-O bond cleavage is facilitated by the chelation of countercations. This protocol offers a convenient and step-economic route to γ-lactams starting from the corresponding carboxylic acids.