732-34-3

Upstream product

• 789-96-8 (2-chloro-5-(trifluoromethyl)phenyl)(phenyl)methanone 
• 93-58-3 benzoic acid methyl ester 
• 141940-37-6 tert-butyl (4-(trifluoromethyl)phenyl)carbamate 
• 328-87-0 2-chloro-5-(trifluoromethyl)benzonitrile 
• 2358-09-0 2-Amino-5-trifluormethylbenzophenonimin 
• 121-50-6 3-amino-4-chlorobenzotrifluoride 

Downstream Products

• 18509-89-2 5-Trifluormethyl-2--benzophenon 
• 851-74-1 2-Bromacetamido-5-trifluormethyl-benzophenon 
• 5219-89-6 3-Amino-4-phenyl-6-trifluoromethyl-1H-quinolin-2-one 
• 128831-57-2 2-(2-nitrovinyl amino)-5-trifluoromethylbenzophenone 
• 1433904-04-1 4-phenyl-3-(1H-tetrazol-5-yl)-6-trifluoromethyl-1H-quinolin-2-one 
• 69559-51-9 2'-benzoyl-2,2,2-trichloro-4'-trifluoromethylacetanilide 
• 973-24-0 2-aminoacetamido-5-(trifluoromethyl)benzophenone 
• 21237-67-2 N-(2-Benzoyl-4-trifluoromethyl-phenyl)-2-chloro-acetamide 
• 1433902-52-3 4-phenyl-2-(piperidin-1-yl)-3-(1H-tetrazol-5-yl)-6-(trifluoromethyl)quinoline 
• 1433904-05-2 2-chloro-4-phenyl-3-(1H-tetrazol-5-yl)-6-trifluoromethyl-quinoline 

Relevant academic research and scientific papers

QUINOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS

Disclosed herein are certain quinolinone derivatives of Formula (A) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors

We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.