73214-25-2

Basic information

• Product Name: 1,2,4-Triazin-3(2H)-one, 6-phenyl-, hydrazone
• CAS NO: 73214-25-2
• Molecular Formula: C9H9N5
• Molecular Weight: 187.204
• Mol File: 73214-25-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,2,4-Triazin-3(2H)-one, 6-phenyl-, hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazin-3(2H)-one, 6-phenyl-, hydrazone(73214-25-2)
• EPA Substance Registry System: 1,2,4-Triazin-3(2H)-one, 6-phenyl-, hydrazone(73214-25-2)

Safety Data

• Hazardous Substances Data: 73214-25-2(Hazardous Substances Data)

Upstream product

• 73214-24-1 3-chloro-6-phenyl-1,2,4-triazine 
• 6175-45-7 2,2-diethoxyacetophenone 
• 27623-10-5 3-(methylsulfanyl)-6-phenyl-1,2,4-triazine 
• 1380345-03-8 3-methylsulfinyl-6-phenyl-1,2,4-triazine 
• 98-86-2 acetophenone 
• 1074-12-0 phenylglyoxal hydrate 

Downstream Products

• 1380344-32-0 6-((6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline 
• 1380344-68-2 6-(difluoro(6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline 
• 88282-03-5 2-[(6-Phenyl-[1,2,4]triazin-3-yl)-hydrazono]-propionic acid 
• 88282-02-4 2-[(6-Phenyl-[1,2,4]triazin-3-yl)-hydrazono]-propionic acid ethyl ester 

Relevant articles and documents

[1,2,4]TRIAZOLO[4,3-B][1,2,4]TRIAZINE COMPOUND, PREPARATION METHOD AND USE THEREOF

The present invention relates to a structurally novel [1,2,4]triazolo[4,3-b][1,2,4]triazine compounds represented by formula (I) or formula (II), pharmaceutically acceptable salts thereof, prodrugs thereof, hydrates or solvates thereof, and also relates to a preparation method of the compounds, a pharmaceutical composition comprising a therapeutically effective amount of the compounds, as well as the use thereof as protein tyrosine kinase inhibitors, particularly as c-Met inhibitors, in the preparation of medicaments for the prevention and/or treatment of diseases associated with c-Met abnormality.

Studies on Heterocyclic Compounds. Part VI: Synthesis of Bridgehead Nitrogen Triazine and Pyrimidine Heterocycles

New bridgehead nitrogen containing heterocycles such as thiazolotriazine (IVa and IVb), imidazolotriazine (IVc), triazinotriazine (IVd and IVe) and oxadiazolotriazine (IVf) and several of their derivatives (V) have been prepared by reacting their respective hydrazine (II) with ethylpyruvate and phenyl glycoxalic acid.The diazotization of hydrazine (II) furnished the reactive intermediates (VI) (azido form) and (VII) (tetrazole form) depending on the structure of hydrazines.These intermediates have been used to synthesise bridgehead nitrogen pyrimidine derivatives (VIII) by reacting them with diethyl fumarate.The spectral and chemical evidences show that diazotised products obtained from 2-hydrazino-4-phenyl thiazole (IIa) and 2-hydrazino benzothiazole (IIb) exist in tetrazole form (VIIa) and (VIIb), respectively, whereas the remaining four (IIa-IIf) remain in the azido form (VIc-VIf) in the solid state.