73270-33-4

Upstream product

• 554-12-1 propanoic acid methyl ester 
• 2129-89-7 diphenyl(methyl)phosphine oxide 
• 1079-66-9 chloro-diphenylphosphine 
• 33715-08-1 buta-1,2-dien-1-yl diphenyl phosphine oxide 
• 1733-52-4 1-(diphenylphosphinoyl)propan-2-one 
• 74-88-4 methyl iodide 
• 131516-38-6 (E)-diphenyl<2-(2'-propenyloxy)-1-butenyl>phosphine oxide 

Downstream Products

• 821770-42-7 (E)-1-diphenylphosphinoyl-3-methyl-6-phenyl-hex-5-en-2-one 
• 910912-39-9 (4RS,6RS)-(E)-diphenylphosphinoyl-4-methyl-1-phenyl-nona-1,8-dien-5-one 

Relevant academic research and scientific papers

Diphenylphosphinoyl-mediated synthesis of ketones

α-Diphenylphosphinoyl ketones are selectively and sequentially alkylated at the α-position. Double lithiation and selective alkylation occurs at the less stabilised γ-position. Dephosphinoylation of the alkylation products gives ketones. Mono-alkylation is selective, highly crystalline intermediates are formed and a one-pot strategy is possible. The method is ideally suited for the preparation of acid-sensitive ketones. The Royal Society of Chemistry 2006.

Carbanion-Accelerated Claisen Rearrangements. 7. Phosphine Oxide and Phosphonate Anion Stabilizing Groups

The utility of phosphine oxide and phosphonate groups has been examined in the context of the carbanion-accelerated Claisen rearrangement (CACR).Both of the groups permit the construction of substituted allyl vinyl ethers by allyl oxide addition to phosph

Reactions of Anions from α-Diphenylphosphinoyl Ketones with Electrophiles

Anions from α-Ph2P(O)-ketones do not give Horner-Wittig reactions but do react with alkyl halides, including α-halogenocarbonyl compounds, and Michael acceptors.The products may be stereoselectively reduced.