73301-01-6

Basic information

• Product Name: 2,3-dihydroxypropyl 4-chlorobenzoate
• Synonyms: Benzoic acid, 4-chloro-, 2,3-dihydroxypropyl ester
• CAS NO: 73301-01-6
• Molecular Formula: C₁₀H₁₁ClO₄
• Molecular Weight: 230.6449
• Mol File: 73301-01-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 408.2°C at 760 mmHg
• Flash Point: 200.7°C
• Density: 1.375g/cm³
• Vapor Pressure: 2.14E-07mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 2,3-dihydroxypropyl 4-chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydroxypropyl 4-chlorobenzoate(73301-01-6)
• EPA Substance Registry System: 2,3-dihydroxypropyl 4-chlorobenzoate(73301-01-6)

Safety Data

• Hazardous Substances Data: 73301-01-6(Hazardous Substances Data)

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 108636-57-3 (2,2-dimethyl-1,3-dioxolane-4-yl)methyl p-chlorobenzoate 
• 56-81-5 glycerol 
• 74-11-3 para-chlorobenzoic acid 
• 67-56-1 methanol 

Downstream Products

• 108636-58-4 4-chlorobenzoyloxyacetaldehyde 
• 108636-61-9 (3R,4R)-3-benzyloxycarbonylamino-4-(p-chlorobenzoyloxymethyl)-1-<(1S)-1-methoxycarbonyl-2-methylpropyl>-2-azetidinone 
• 108636-61-9 (3S,4S)-3-benzyloxycarbonylamino-4-(p-chlorobenzoyloxymethyl)-1-<(1S)-1-methoxycarbonyl-2-methylpropyl>-2-azetidinone 

Relevant articles and documents

HPLC analysis of indomethacin and its impurities in capsule and suppository formulations

Indomethacin and its impurities in suppository and capsule formulations were quantitatively determined by HPLC using a reversed-phase, octadecyl column and a mobile phase of methanol-water-acetonitrile-acetic acid (55:35:10:1). Analysis of the suppository formulations provided a mean potency for indomethacin of 103.8%. The same formulation was found to contain 4-chlorobenzoic acid (0.02%), 5-methoxy-2-methyl-3-indoleacetic acid (0.007%), 4-chlorobenzoic acid-α-monoglyceride (0.39%), and indomethacin-α-monoglyceride (0.9%) as impurities. The latter two impurities were a result of the interaction of indomethacin and 4-chlorobenzoic acid with glycerin used in the suppository base. Capsule formulations were likewise assayed with an average potency of 99.9 and 101.5% for 25- and 50-mg dosage forms, respectively. Only one of the two capsule formulations examined contained detectable qauantities of 4-chlorobenzoic acid (0.05%).

Mercuriation and Thalliation of Polystyrene: Conversion of the Products into Polystyrenes containing Iodobenzene, Phenylboronic Acid, and Phenol Residues

Linear and 1percent crosslinked polystyrenes were mercuriated and thalliated.Treatment of the mercuriated products with iodine and the thalliated products with potassium iodide gave iodinated polystyrenes.The metallated polymers reacted with borane to give polymer-supported arylboranes, and these on treatment with water gave polystyrenes containing phenylboronic acid residues.The latter can be used as polymer-supported protecting groups for diols.Oxidation of the polymers containing phenylboronic acid residues with trimethylamine oxide or with alkaline hydrogen peroxide gave polymers containing phenol residues.

A STUDY ON THE SYNTHESIS OF CARUMONAM STARTING FROM AN α-AMINO ACID

As part of a study on the synthesis of carumonam (1), a method starting from an α-amino acid was investigated.Cycloaddition of the mixed anhydride, derived from carbobenzoxyglycine (7) and isopropyl chloroformate, with the chiral imine (11b), derived from