73365-03-4

Basic information

• Product Name: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal
• Synonyms: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal
• CAS NO: 73365-03-4
• Molecular Weight: 203.197
• Mol File: 73365-03-4.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal(73365-03-4)
• EPA Substance Registry System: 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal(73365-03-4)

Safety Data

• Hazardous Substances Data: 73365-03-4(Hazardous Substances Data)

Upstream product

• 2453-90-9 N-(3,3-diethoxypropyl)phthalimide 
• 3485-84-5 N-vinylphthalimide 
• 136918-14-4 phthalimide 
• 105763-33-5 (2R,3R)-2-phthalimidobutane-1,2-diol 
• 201230-82-2 carbon monoxide 
• 50-00-0 formaldehyd 
• 32304-36-2 (+/-)N-(2-oxo-thietan-3-yl)-phthalimide 
• 53701-47-6 2-(1,3-dioxoisoindolin-2-yl)propanoyl chloride 
• 19967-57-8 bromo-2 propanal 
• 1074-82-4 potassium phtalimide 
• 105763-25-5 (2R,3R)-1,2-O-isopropylidene-3-phthalimidobutane-1,2-diol 
• 53100-40-6 (2R)-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanoylchloride 
• 29588-83-8 (R)-N-phthaloylalanine 

Downstream Products

• 29588-83-8 (R)-N-phthaloylalanine 
• 4192-28-3 Phth-L-Ala-OH 
• 184765-67-1 2-{1-Methyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione 
• 82353-61-5 (R)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-methyl-pentanethioic acid S-phenyl ester 
• 82353-61-5 (2R,3S,4S)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-methyl-pentanethioic acid S-phenyl ester 
• 3738-61-2 (+/-)-N-[β-(2,4-dinitro-phenylhydrazono)-isopropyl]-phthalimide 

Relevant articles and documents

Effector enhanced enantioselective hydroformylation

In this communication, we report rhodium DIMPhos complexes with an integrated DIM-receptor that can bind carboxylate containing effectors and their application in the rhodium catalyzed hydroformylation reaction. The binding of chiral effectors in non-chiral [Rh(DIMPhos)] catalysts does not lead to enantioselective hydroformylation, but the binding of either achiral or chiral effectors can significantly enhance the enantioselectivity induced by the chiral Rh-metal complexes. For example, the supramolecular complex [Rh]/[1S?L3] displays high regio- and enantioselectivity in the hydroformylation of vinyl acetate (72% ee, and b/l >99), whereas in absence of this effector the ee is around 17%.

KetoABNO/NOx Cocatalytic Aerobic Oxidation of Aldehydes to Carboxylic Acids and Access to α-Chiral Carboxylic Acids via Sequential Asymmetric Hydroformylation/Oxidation

A method for aerobic oxidation of aldehydes to carboxylic acids has been developed using organic nitroxyl and NOx cocatalysts. KetoABNO (9-azabicyclo[3.3.1]nonan-3-one N-oxyl) and NaNO2 were identified as the optimal nitroxyl and NOx sources, respectively. The mildness of the reaction conditions enables sequential asymmetric hydroformylation of alkenes/aerobic aldehyde oxidation to access α-chiral carboxylic acids without racemization. The scope, utility, and limitations of the oxidation method are further evaluated with a series of achiral aldehydes bearing diverse functional groups.

New tetraphosphorus ligands for highly linear selective hydroformylation of allyl and vinyl derivatives

New tetraphosphorus ligands have been developed and applied in the rhodium-catalyzed regioselective hydroformylation of a variety of functionalized allyl and vinyl derivatives. Remarkably high linear selectivity was obtained by these tetraphosphorus ligands. The ligand that bears strong electron-withdrawing 2,4-difluorophenyl groups is the most effective one in affording linear aldehydes. The Rh/tetraphosphorus ligand catalyst is highly effective to produce linear aldehydes from functionalized allyl derivatives with heteroatoms or aromatic groups directly adjacent to the allyl group. For vinyl derivatives, the ligand is highly linear selective for acrylic derivatives, styrene, vinyl pyridine, and vinyl phthalimide. Linear to branch ratios of 26:1 and 10:1 were obtained for the hydroformylation of styrene and allyl cyanide, respectively. New tetraphosphorus ligands have been developed and applied in the rhodium-catalyzed regioselective hydroformylation of a variety of allyl and vinyl olefins (see scheme). Remarkably high linear selectivities were obtained by these ligands. Linear-to-branch ratios of 26:1 and 10:1 were obtained for the hydroformylation of styrene and allyl cyanide, respectively. Copyright