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Relevant academic research and scientific papers

MOF-5 as a highly efficient and recyclable catalyst for one pot synthesis of 2,4-disubstituted quinoline derivatives

A MOF-5-catalyzed three-component coupling reaction was developed as an efficient approach for the synthesis of 2,4-disubstituted quinoline derivatives via a one pot three-component reaction of aromatic amines, aldehydes and alkynes with excellent yields. The easy recovery and reusability of the catalyst, broad substrate scope, short reaction time, high yields of products and solvent-free conditions make this protocol practical, environmentally friendly and economically attractive.

Manganese(ii)-catalysed dehydrogenative annulation involving C-C bond formation: highly regioselective synthesis of quinolines

An inexpensive nontoxic manganese(ii)-catalysed dehydrogenative annulation was developed for C-C bond formation. The reaction showed high selectivity and efficiency across a broad substrate scope. Remarkably simple conditions and the ability to conduct gram-scale synthesis underscore this method's utility. To demonstrate the potential of this approach, we tested the drug effects of compound 3n, which showed activity for blocking vascular development. The results of this study will be important for the treatment of eye diseases and tumors caused by vascular proliferation.

Quinoline-containing skeleton compound and preparation method and applications thereof

The invention discloses a quinoline-containing skeleton compound and a preparation method thereof. A structural formula of the compound is represented by a formula I shown in the description. According to the invention, a series of quinoline derivatives are efficiently and rapidly synthesized by adopting cheap metal catalysis technology. The compound has a pharmaceutical effect on nervous system diseases and vascular system diseases, and broadens a treatment range of quinoline medicine.

Acid-promoted iron-catalysed dehydrogenative [4 + 2] cycloaddition for the synthesis of quinolines under air

An acid-promoted iron-catalysed dehydrogenative [4 + 2] cycloaddition reaction was developed for the synthesis of quinolines using air as a terminal oxidant. Acetic acid was the best cocatalyst for the cycloaddition of N-alkyl anilines with alkenes or alk

Ligand promoted method for synthesizing polysubstituted quinoline under catalysis of cheap metal

The invention discloses a ligand promoted method for synthesizing polysubstituted quinoline under the catalysis of cheap metal. According to the method disclosed by the invention, a substituted arylamine compound and a substituted olefin compound are used

Enantioselective Metal-Free Hydrogenations of Disubstituted Quinolines

A metal-free hydrogenation of 2,4-disubstituted quinolines was realized for the first time using chiral diene derived borane catalysts to furnish the corresponding tetrahydroquinolines in 75-98% yields with 95/5-99/1 dr's and 86-98% ee's. This catalytic system was also effective for 2,3-disubstituted quinolines to give moderate to good ee's.

Formal [4+2]-annulation of vinyl azides with N-unsaturated aldimines

Highly functionalized quinolines and pyridines could be synthesized by BF3?OEt2-mediated reactions of vinyl azides with N-aryl and N-alkenyl aldimines, respectively. The reaction mechanism could be characterized as formal [4+2]-annulation, including unprecedented enamine-type nucleophilic attack of vinyl azides to aldimines and subsequent nucleophilic cyclization onto the resulting iminodiazonium ion moieties.

Palladium-catalyzed sequential formation of C-C bonds: Efficient assembly of 2-substituted and 2,3-disubstituted quinolines

A series of substituted quinolines was prepared from arylamines, aldehydes, and terminal olefins (see scheme). The palladium-catalyzed sequential formation of C-C bonds proceeds smoothly with both electron-deficient and electron-rich olefins. When acrylic acid is used as terminal olefin, decarboxylation occurs to provide 2-substituted quinolines. Copyright