73492-35-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-bromophenyl)-2,2-dimethylpropan-1-ol is used as a nasal decongestant for the temporary relief of nasal congestion. It works by constricting the blood vessels in the nasal passages, which helps to alleviate swelling and congestion, leading to improved breathing and relief from symptoms associated with allergies, sinusitis, and the common cold.
Used in Over-the-counter Medications:
1-(4-bromophenyl)-2,2-dimethylpropan-1-ol is used as an active ingredient in over-the-counter nasal sprays and drops. These products are widely available in many countries and are designed to provide quick and effective relief from nasal congestion for consumers who are seeking temporary relief from their symptoms.

Upstream product

• 2259-30-5 tert-butylmagnesium bromide 
• 1122-91-4 4-bromo-benzaldehyde 
• 677-22-5 tert-butylmagnesium chloride 
• 3282-30-2 pivaloyl chloride 
• 106-37-6 1.4-dibromobenzene 
• 6999-03-7 1-bromo-4-(trimethylsilyl)benzene 
• 630-19-3 pivalaldehyde 
• 30314-45-5 1-(4-bromophenyl)-2,2-dimethylpropan-1-one 
• 507-20-0 tertiary butyl chloride 

Downstream Products

• 1360551-92-3 2-(4-bromo-phenyl)-3,3-dimethylbutyronitrile 
• 31006-99-2 3,3-dimethyl-2-(4-bromophenyl)-1-butene 
• 30314-45-5 1-(4-bromophenyl)-2,2-dimethylpropan-1-one 
• 1236357-62-2 (1-(4-bromophenyl)-2,2-dimethylpropoxy)(tert-butyl)dimethylsilane 
• 120136-07-4 Toluene-4-sulfonic acid 1-(4-bromo-phenyl)-2,2-dimethyl-propyl ester 
• 86696-33-5 1-Chlor-2,2-dimethyl-1-(4-brom-phenyl)-propan 

Relevant academic research and scientific papers

AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS

The present invention is directed to amide compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful in the treatment or prevention of diseases or disorders associated with peripheral serotonin including, for example, gastrointestinal, cardiovascular, pulmonary, inflammatory, metabolic, fibrotic, and low bone mass diseases, as well as cancer.

OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION FOR COMBINATION THERAPY

The present invention relates to combination therapy using compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein and an additional pharmaceutically active agent. The invention also relates to pharmaceutical compositions comprising these combinations, and methods of using these combinations in the treatment of various diseases and disorders.

OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

4-AMINO-5-OXO-7, 8-DIHYDROPYRIMIDO [5,4-F] [1,4] OXAZEPIN-6 (5H) -YL) PHENYL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The invention provides compounds of Formula (I), wherein R1, R2a, R2b, R3, m and A are as defined herein, as well as compositions thereof and methods for treating a disease, condition or disorder that is modulated by the inhibition of the diacylglycerol O-acyltransferase 1 (DGAT-1) enzyme by administering the compounds of the present invention and/or compositions thereof.

4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES

The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.

Copper-catalyzed hydrosilylation with a bowl-shaped phosphane ligand: Preferential reduction of a bulky ketone in the presence of an aldehyde

Chemical Equation Presented Hollywood bowl: A highly active copper catalyst with a bowl-shaped phosphane (bsp) ligand was used in the hydrosilylation reaction of bulky ketones. The preferential reduction of a bulky ketone in the presence of an unprotected aldehyde is unprecedented.

Phosphazene base-promoted functionalization of aryltrimethylsilanes

The activation of Ar-Si bonds in aryltrimethylsilane was investigated using a catalytic amount of t-Bu-P4 base and selective functionalizations of aryltrimethylsilanes in the absence of strong electron withdrawing groups on the aromatic rings were accomplished. The Royal Society of Chemistry 2006.