73501-53-8Relevant articles and documents
Method for promoting synthesis of beta-hydroxyl selenide compound by visible light
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Paragraph 0070-0073, (2021/05/01)
The invention relates to the technical field of organic synthetic chemistry, in particular to a method for promoting synthesis of a beta-hydroxyl selenide compound by visible light. The method comprises the following steps: A, sequentially adding a compound 1 and a compound 2 into a reactor; B, stirring the compound 1 and the compound 2 for reaction at a certain temperature under the irradiation of a light source under an open condition; C, after the reaction is finished, evaporating the solvent under reduced pressure to obtain a crude product; and D, carrying out column chromatography purification to obtain the beta-hydroxy selenide compound 3. According to the method, olefin and diselenide are used as raw materials, one of an acetonitrile/water mixed solvent and an acetone/water mixed solvent is used as a solvent, the reaction temperature is room temperature, and the beta-hydroxyl selenide compound is efficiently synthesized under the irradiation of a white fluorescent light source; compared with the traditional synthesis method, the method has the advantages that the reaction conditions are mild and can be smoothly carried out at room temperature; operation is simple, and all operations can be carried out in an open system; and raw materials are easy to obtain, the yield is high, functional group compatibility is good, and the substrate application range is wide.
Preparation method of beta-hydroxyphenyl selenide compound
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Paragraph 0068; 0069; 0070; 0071-0076; 0159; 0160-0162, (2017/12/27)
The invention relates to the technical field of synthesis of organic compounds and particularly relates to a preparation method of a beta-hydroxyphenyl selenide compound. The preparation method comprises the step of with aryl boronic acid with a structure presented by a formula (I), elemental selenium and an ethylene oxide derivative presented by a formula (II) as the raw materials, and carrying out insertion reaction on elemental selenium in a reaction solvent under the common effect of a copper catalyst, silver salt and alkali, so as to obtain the beta-hydroxyphenyl selenide compound represented by a formula (III), wherein R1 and R2 are respectively independently selected from one of H, a benzene ring, a naphthalene ring, a heterocyclic ring, a substituted benzene ring, linear alkyl, branched chain, halogen, nitryl and a cyano group.
A β- hydroxyl selenium etheration method for synthesizing compound of
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Paragraph 0076-0079, (2017/03/08)
The invention relates to a synthetic method of Beta-hydroxyl selenide compound. The method includes: in organic solvent, in the presence of catalyst and alkali, allowing halogenated compound to react with elemental Se and epoxy compound to obtain Beta-hydroxyl selenide compound. The synthetic method has the advantages that reaction is simple, operating is simple, yield is high, the method is a novel one, a novel synthetic route is provided for the synthesis of the Beta-hydroxyl selenide compounds, and the method has good scientific research value and industrial potential.
