7352-02-5

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 2-CYANO-4-METHYLVALERATE is used as a synthetic intermediate for the development of various pharmaceutical products. Its unique structure allows it to be a key component in the synthesis of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 2-CYANO-4-METHYLVALERATE is utilized as a synthetic intermediate in the creation of pesticides and other agricultural chemicals. Its properties make it suitable for enhancing the effectiveness of these products and supporting agricultural productivity.
Used in Organic Synthesis:
ETHYL 2-CYANO-4-METHYLVALERATE is employed as a reagent in organic synthesis, where it plays a crucial role in various chemical reactions. Its distinctive structure facilitates the formation of new compounds and contributes to the broader field of organic chemistry.
Used in Chemical Reactions:
As a reagent in chemical reactions, ETHYL 2-CYANO-4-METHYLVALERATE is instrumental in facilitating specific transformations and processes. Its application in these reactions is essential for achieving desired outcomes in chemical research and industrial applications.

InChI:InChI=1/C9H15NO2/c1-4-12-9(11)8(6-10)5-7(2)3/h7-8H,4-5H2,1-3H3

Upstream product

• 513-38-2 Isobutyl iodide 
• 18852-51-2 sodium cyanoacetic acid ethyl ester 
• 78-84-2 isobutyraldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 78-77-3 Isobutyl bromide 
• 871900-41-3 2-cyano-2-isobutyl-4-methyl-valeric acid 
• 75-03-6 ethyl iodide 
• 141-52-6 sodium ethanolate 
• 868-47-3 (E)-ethyl 2-cyano-4-methylpent-2-enoate 

Downstream Products

• 4431-58-7 2-isobutyl-malonamic acid 
• 93341-04-9 2-isobutyl-malonamic acid ethyl ester 
• 18283-06-2 2-Ethoxycarbonimidoyl-2-fluoro-4-methyl-pentanoic acid ethyl ester 
• 18283-41-5 2-cyano-4-methylpentanoic acid 
• 18283-15-3 2-Cyano-2-fluoro-4-methyl-pentanoic acid ethyl ester 
• 181289-39-4 (S)-3-cyano-5-methylhexanoic acid ethyl ester 
• 1445579-46-3 ethyl 2-cyano-2-(4-methoxyphenyl)-4-methylpentanoate 
• 18283-33-5 2-Fluoro-2-isobutyl-malonamide 
• 18283-38-0 2-Carbamoyl-2-fluoro-4-methyl-pentanoic acid 
• 6087-17-8 2-fluoro-4-methylpentanoic acid 
• 181289-16-7 racemic 3-cyano-5-methylhexanoic acid 
• 148553-50-8 pregabilin 

Relevant academic research and scientific papers

Room Temperature, Reductive Alkylation of Activated Methylene Compounds: Carbon-Carbon Bond Formation Driven by the Rhodium-Catalyzed Water-Gas Shift Reaction

The rhodium-catalyzed water-gas shift reaction has been demonstrated to drive the reductive alkylation of several classes of activated methylene compounds at room temperature. Under catalysis by rhodium trichloride (2-3 mol %), carbon monoxide (10 bar), water (2-50 equiv), and triethylamine (2.5-7 equiv), the scope has been successfully expanded to cover a wide range of alkylating agents, including aliphatic and aromatic aldehydes, as well as cyclic ketones, in moderate to high yields. This method is comparable to, and for certain aspects, surpasses the established reductive alkylation protocols.

PROCESS FOR SYNTHESIS OF (S) - PREGABALIN

Improved process for the synthesis of (S)-pregabalin having more than 99% ee through (S) 3-cyano-5-methyl-hexanoic acid has been developed. In addition to above, a novel process for resolution of (RS) - 3-cyano-5-methyl-hexanoic acid through diastereomeric salt formation with cinchonidine to obtain (S) - 3-cyano-5-methyl-hexanoic acid in high yield and high optical purity has been developed and furthermore process for recovery/ reuse of cinchonidine is also developed to improve the overall process efficiency.

IMPROVED SYNTHESIS OF OPTICALLY PURE (S) - 3-CYANO-5-METHYL-HEXANOIC ACID ALKYL ESTER, AN INTERMEDIATE OF (S)- PREGABALIN

The present invention is directed towards synthesis of (S) - 3-cyano-5-methyl-hexanoic acid ethyl ester. A cost effective, eco-friendly process for preparation of enantiomerically pure (S)-3-cyano-5-methyl-hexanoic acid alkyl ester, intermediate of γ-amino acids, particularly (S)-pregabalin.

Environmentally friendly one-pot synthesis of α-alkylated nitriles using hydrotalcite-supported metal species as multifunctional solid catalysts

A ruthenium-grafted hydrotalcite (Ru/HT) and hydrotalcite-supported palladium nanoparticles (Pdnano/ HT) are easily prepared by treating basic layered double hydroxide, hydrotalcite (HT, Mg6Al 2(OH)16CO3) with aqueous RuCl 3·n H2O and K2[PdCl4] solutions, respectively, using surface impregnation methods. Analysis by means of X-ray diffraction, and energydispersive X-ray, electron paramagnetic resonance, and X-ray absorption fine structure spectroscopies proves that a monomeric RuIV species is grafted onto the surface of the HT. Meanwhile, after reduction of a surface-isolated PdII species, highly dispersed Pd nanoclusters with a mean diameter of about 70 A is observed on the Pdnano/HT surface by transmission electron microscopy analysis. These hydrotalcite-supported metal catalysts can effectively promote α-alkylation reactions of various nitriles with primary alcohols or carbonyl compounds through tandem reactions consisting of metal-catalyzed oxidation and reduction, and an aldol reaction promoted by the base sites of the HT. In these catalytic α-alkylations, homogeneous bases are unnecessary and the only by-product is water. Additionally, these catalyst systems are applicable to one-pot syntheses of glutaronitrile derivatives.