73520-87-3

Basic information

• Product Name: Benzene, 1-(dodecylthio)-4-nitro-
• Synonyms: 1-dodecylthio-4-nitrobenzene;Benzene,1-(dodecylthio)-4-nitro;4-Nitro-1-dodecylmercapto-benzol;p-nitrophenyl n-dodecyl thioether;Dodecyl-(4-nitro-phenyl)-sulfid;dodecyl-(4-nitro-phenyl)-sulfide;4-Nitrophenyl-n-dodecyl-sulfid
• CAS NO: 73520-87-3
• Molecular Formula: C18H29NO2S
• Molecular Weight: 323.5
• Mol File: 73520-87-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 49.0-51.5 °C
• Boiling Point: 439.3±28.0 °C(Predicted)
• Density: 1.03±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 1-(dodecylthio)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(dodecylthio)-4-nitro-(73520-87-3)
• EPA Substance Registry System: Benzene, 1-(dodecylthio)-4-nitro-(73520-87-3)

Safety Data

• Hazardous Substances Data: 73520-87-3(Hazardous Substances Data)

Upstream product

• 1849-36-1 para-nitrobenzenethiol 
• 701-57-5 1-methylthio-4-nitro-benzene 
• 112-55-0 1-dodecylthiol 
• 636-98-6 p-nitrobenzene iodide 
• 100-25-4 para-dinitrobenzene 
• 350-46-9 4-Fluoronitrobenzene 
• 3076-63-9 tridodecyl phosphite 
• 2137-92-0 4-nitrophenyl thiocyanate 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 143-15-7 1-dodecylbromide 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 26960-77-0 sodium dodecanethiolate 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 21232-29-1 4-n-dodecylsulfanylphenylamine 
• 94261-92-4 Dodecyl-(4-nitrophenyl)-sulfon 

Relevant articles and documents

Transition-Metal-Free Aryl-Heteroatom Bond Formation via C-S Bond Cleavage

Aryl-heteroatom bonds (C-Het) are almost ubiquitously present in chemical molecules. However, methods for diverse C-Het bond formations from a simple substrate are limited. Herein, we report a convenient and efficient C-S bond transformation of aryl sulfoniums to various C-Het bonds (C-O, C-S, C-Sn, C-Si, C-Se) in the absence of any transition-metal catalyst. These reactions proceeded in mild conditions with a wide substrate scope.

The [Cu]-catalyzed SNAR reactions: Direct amination of electron deficient aryl halides with sodium azide and the synthesis of arylthioethers under Cu(II) - Ascorbate redox system

A one pot [Cu]-promoted SNAr reaction of electron-deficient halobenzenes with sodium azide and the reduction of the intermediate aryl azides under the same Cu(II)-ascorbate redox conditions leading to anilines has been documented. Control experiments revealed that both ascorbate and proline play important role in the reaction path way. Further, the use of this catalytic Cu(II)-ascorbate redox system has been explored for the synthesis of arylthioethers.

Nucleophilic aromatic substitution reaction of nitroarenes with alkyl- or arylthio groups in dimethyl sulfoxide by means of cesium carbonate

Treatment of nitroarenes having electron-withdrawing groups at the ortho or para position with alkanethiol in the presence of cesium carbonate in dimethyl sulfoxide at 25°C leads to nucleophilic displacement of the nitro group with the alkylthio group. Cesium carbonate is superior to other bases such as potassium carbonate, sodium carbonate, and triethylamine. The cesium-mediated nucleophilic aromatic substitution reaction provides a mild yet powerful and user-friendly protocol for the synthesis of aryl sulfides.