735278-45-2

Upstream product

• 232618-88-1 (2R,5S)-2-dimethylamino-3-phenyl-1,3-diazaphosphabicyclo[3.3.0^1,5]octane 
• 108-95-2 phenol 
• 569669-56-3 (3aS)-1-chloro-2-phenyl-hexahydro-1H-pyrrolo[1,2-c][1,3,2]diazaphosphole 
• 64030-44-0 (2S)-2-(anilinomethyl)pyrrolidine 

Downstream Products

• 207129-48-4 (2S,5S)-2-(2-hydroxyphenyl)-3-phenyl-1,3-diaza-2-phosphabicyclo[3.3.0]octane 2-oxide 
• 261162-68-9 (1S,3aS)-1-Phenoxy-2-phenyl-hexahydro-pyrrolo[1,2-c][1,3,2]diazaphosphole 1-oxide 

Relevant academic research and scientific papers

Looking for a synergic effect between NHCs and chiral P-ligands

(Graph Presented) The issue of the added value of NHCs in asymmetric catalysis with respect to trusted chiral P-ligands was addressed: considering a prototypical asymmetric allylic alkylation reaction as a model, the association of a priori inhibiting and

P-chiral monodentate diamidophosphites - New and efficient ligands for palladium-catalysed asymmetric allylic substitution

Novel P*-monodentate diamidophosphite ligands have been prepared by a one-step phosphorylation of alcohols or amines. Both the electronic and the steric demands of the ligands have been estimated quantitatively. Neutral [Pd(allyl)Cl(L)] and cationic [Pd(a

Scope and limitations of the aromatic anionic [1,3] P-O to P-C rearrangement in the synthesis of chiral o-hydroxyaryl diazaphosphonamides

The influence of numerous parameters in the aromatic anionic [1,3] P-O to P-C rearrangement in the synthesis of chiral o-hydroxyaryl diazaphosphonamides has been envisaged. Various strong bases such as LDA, sec-BuLi, tert-BuLi have been conveniently used. The scope of the regioselectivity of the rearrangement has been particularly studied varying the nature of the phenoxy group implied in this reaction. A totally diastereoselective P-O to P-C migration rearrangement has been observed starting from a thiophosphonamide precursor. Moreover, starting from a phenylthio substituted phosphonamide, a totally diastereoselective P-S to P-C rearrangement of the diazaphosphonamide moiety has also been demonstrated. (C) 2000 Elsevier Science Ltd.

Totally stereoselective P-O to P-C migration rearrangement: Application to the synthesis of new chiral O-hydroxyaryl phosphine oxides

The synthesis of a novel class of chiral o-hydroxyaryl phosphine oxides by the rearrangement of a P-O to a P-C bond is described. This reaction proceeds with excellent yields (75-95%) and total retention of the configuration on the phosphorus atom. In the case of the treatment of an equimolar mixture of the diastereomers anti-2e and syn-2f, the resulting compounds anti-3e and syn-3f, obtained in a 1:1 molar ratio, were separated and characterized by X-ray diffraction. On the basis of the experimental results, we suggest that the migration mechanism is addition-pseudorotation-elimination; this explains the total stereoselectivity observed at the phosphorus atom.