73607-12-2

Upstream product

• 791-50-4 2,2,4,4-Tetrakis(trifluoromethyl)-1,3-dithietane 
• 123-11-5 4-methoxy-benzaldehyde 
• 1652-80-8 2,2-dichloro-1,1,1,3,3,3-hexafluoro-propane 
• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 
• 77152-08-0 trifluoromethylcopper(I) 
• 82203-83-6 1-(p-methoxyphenyl)-3,3,3-trifluoropropyne 

Relevant academic research and scientific papers

Domino Hydroboration/Trifluoromethylation of Alkynes Using Fluoroform-Derived [CuCF3]

A domino hydroboration/trifluoromethylation (formal hydrotrifluoromethylation) of alkynes using the fluoroform-derived [CuCF3] reagent is achieved. Synthetically useful (E)-alkenyl-CF3 building blocks and 1,1-bis(trifluoromethyl)-substituted alkenes can be prepared under ambient conditions in one pot/one step from alkynes. The ultimate source of CF3 is the inexpensive industrial waste fluoroform.

The trifluoromethylation of 1,1-dibromo-1-alkenes using trifluoromethylcopper (CF3Cu) generated in situ from methyl fluorosulfonyldifluoroacetate

The trifluoromethylation of 2-aryl-1,1-dibromo-1-alkenes with CF3Cu under palladium catalysis gave bistrifluoromethylated compounds (2), whereas under the same reaction conditions, monotrifluoromethylated products (3) were obtained exclusively

A New Synthesis of 1,1-Bis(trifluoromethyl)-Substituted Alkenes

1,1-Bis(trifluoromethyl)-substituted alkenes 6 are obtained by the reaction of aldehydes 5 with triphenylphosphine (4) and 2,2-dichlorohexafluoropropane (3) in modest to good yields.The alkenes 6 are not easily accessible by other routes.