7361-76-4

Basic information

• Product Name: (+)-PENTAZOCINE - DEA SCHEDULE IV ITEM
• Synonyms: (+)-PENTAZOCINE - DEA SCHEDULE IV ITEM;(11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2β,6β-methano-3-benzazocin-8-ol;(11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2β,6β-methano-3-benzazocine-8-ol;(2S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2β,6β-methano-3-benzazocin-8-ol;[2S,6S,11S,(+)]-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocine-8-ol;d-Pentazocine;(2S,6S,11S)-;Pentazozine
• CAS NO: 7361-76-4
• Molecular Formula: C₁₉H₂₇NO
• Molecular Weight: 285.42378
• Product Categories: Agonists;Opioids;Pharmacologicals;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 7361-76-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 403.5±45.0 °C(Predicted)
• Appearance: white/solid
• Density: 1.036±0.06 g/cm3(Predicted)
• PKA: 10.10±0.60(Predicted)
• CAS DataBase Reference: (+)-PENTAZOCINE - DEA SCHEDULE IV ITEM(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-PENTAZOCINE - DEA SCHEDULE IV ITEM(7361-76-4)
• EPA Substance Registry System: (+)-PENTAZOCINE - DEA SCHEDULE IV ITEM(7361-76-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• WGK Germany: 3
• Hazardous Substances Data: 7361-76-4(Hazardous Substances Data)

Usage

Uses

Mixed opioid agonist-antagonist. Controlled substance. Analgesic (narcotic).

Upstream product

• 16603-67-1 (-)-cis-N-Normetazocine 
• 870-63-3 prenyl bromide 
• 1033702-80-5 C₂₁H₂₅NO 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 577991-77-6 [2-((R)-7-Methoxy-1-methyl-2-methylene-1,2,3,4-tetrahydro-naphthalen-1-yl)-ethyl]-(3-methyl-but-2-enyl)-amine 
• 577991-79-8 3-((R)-7-Methoxy-1-methyl-2-methylene-1,2,3,4-tetrahydro-naphthalen-1-yl)-propane-1,2-diol 
• 577991-73-2 (R)-1-Allyl-7-methoxy-1-methyl-2-methylene-1,2,3,4-tetrahydro-naphthalene 
• 577991-72-1 1-allyl-7-methoxy-1-methyl-2-tetralone 
• 577991-74-3 ((R)-7-Methoxy-1-methyl-2-methylene-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetaldehyde 
• 1204-23-5 1-methyl-7-methoxy-2-tetralone 
• 577991-78-7 O-methyl pentazocine 
• 90667-54-2 N-(3-methyl-3-pentenyl)phthalimide 
• 57253-31-3 (E)-5-bromo-3-methylpentyl-2-ene 

Downstream Products

• 71780-69-3 Thiobenzoic acid S-[(6R,11R)-6,11-dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl] ester 
• 83434-65-5 Thiobenzoic acid S-[(2S,6S,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl] ester 
• 83434-64-4 Thiobenzoic acid S-[(2R,6R,11R)-6,11-dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl] ester 
• 83434-65-5 Thiobenzoic acid S-[(2R,6R,11R)-6,11-dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-yl] ester 

Relevant articles and documents

Pentazocine prodrug as well as preparation method and application thereof

The invention discloses a pentazocine prodrug shown as a formula (I), a preparation method thereof and medical application of a pharmaceutical preparation containing the pentazocine prodrug, wherein Ris hydrogen or deuterium. The water solubility of the prodrug compound is improved by 20 times or above at room temperature, the prodrug compound is chemically stable, the onset time is delayed, thedrug effect is prolonged, meanwhile, the same parent drug blood concentration is generated at a low dosage, and the prodrug compound has a wide clinical application prospect.

Enantiocontrolled synthesis of (-)-9-epi-pentazocine and (-)-aphanorphine

(Chemical Equation Presented) We have developed novel asymmetric routes to (-)-9-epi-pentazocine and (-)-aphanorphine from a D-tyrosine derivative. The tricyclic frameworks of (-)-9-epi-pentazocine and (-)-aphanorphine were assembled stereoselectively via intramolecular Friedel-Crafts reaction of the corresponding bicyclic precursors, generated with titanium-promoted enyne cyclization and indium-initiated atom-transfer radical cyclization, respectively.

Migratory hydroamination: A facile enantioselective synthesis of benzomorphans

We describe a highly efficient, general strategy for the enantioselective synthesis of benzomorphans (45-46% overall yield from commercially available material). The new synthesis demonstrates the effectiveness of an unprecedented diastereoselective cycloisomerization via migratory hydroamination and the power of palladium-catalyzed asymmetric allylic alkylation (AAA) of simple ketone enolates in the context of complex synthesis. The strategy outlined here for the enantioselective synthesis of three contiguous stereogenic centers and the novel cycloisomerization should have many applications in alkaloid synthesis. Copyright