73627-18-6

Basic information

• Product Name: 1-METHYL-1,2,3,4-TETRAHYDRO-PYRROLO[1,2-A]PYRAZINE
• Synonyms: 1,2,3,4-Tetrahydro-1-methylpyrrolo[1,2-a]pyrazine;1-methyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine(SALTDATA: HCl 0.1H2O)
• CAS NO: 73627-18-6
• Molecular Formula: C8H12N2
• Molecular Weight: 136.2
• Mol File: 73627-18-6.mol

Chemical Properties

• Boiling Point: 243.4°C at 760 mmHg
• Flash Point: 101°C
• Appearance: /
• Vapor Pressure: 0.0322mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-METHYL-1,2,3,4-TETRAHYDRO-PYRROLO[1,2-A]PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1,2,3,4-TETRAHYDRO-PYRROLO[1,2-A]PYRAZINE(73627-18-6)
• EPA Substance Registry System: 1-METHYL-1,2,3,4-TETRAHYDRO-PYRROLO[1,2-A]PYRAZINE(73627-18-6)

Safety Data

• Hazardous Substances Data: 73627-18-6(Hazardous Substances Data)

Usage

Uses

Used in Research Applications:
1-METHYL-1,2,3,4-TETRAHYDRO-PYRROLO[1,2-A]PYRAZINE is used as a research compound for studying its mutagenicity and carcinogenicity, as well as its effects on neurotransmitter levels in the brain. This helps scientists understand its potential health effects and mechanisms of action.
Used in Pharmaceutical Applications:
1-METHYL-1,2,3,4-TETRAHYDRO-PYRROLO[1,2-A]PYRAZINE is used in the development of pharmaceuticals, leveraging its psychoactive properties to explore its potential therapeutic uses, while also considering its mutagenicity and carcinogenicity to ensure safety in drug design.
Used in Toxicological Studies:
1-METHYL-1,2,3,4-TETRAHYDRO-PYRROLO[1,2-A]PYRAZINE is used as a subject in toxicological studies to investigate its role in the development of certain cancers and to assess the risks associated with its presence in tobacco smoke and certain foods.
Used in Environmental and Occupational Health Assessments:
1-METHYL-1,2,3,4-TETRAHYDRO-PYRROLO[1,2-A]PYRAZINE is used in assessments of environmental and occupational health to determine exposure levels and potential risks to human health, particularly in relation to its presence in tobacco smoke and other sources.

InChI:InChI=1/C8H12N2/c1-7-8-3-2-5-10(8)6-4-9-7/h2-3,5,7,9H,4,6H2,1H3/p+1/t7-/m1/s1

Upstream product

• 73627-16-4 N-[2-(1H-pyrrol-1-yl)ethyl]acetamide 
• 64608-66-8 1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine 
• 1192-62-7 1-(2-furyl)-1-ethanone 
• 107-15-3 ethylenediamine 

Downstream Products

• 1260250-60-9 3-ethyl-6-methyl-5-tosyl-1,2,3,6-tetrahydropyrrolo[1,2-d][1,4]diazocine-9-carbaldehyde 
• 73627-19-7 1,2-Dimethyl-1,2,3,4-tetrahydropyrrolo<1,2-a>pyrazine 
• 1355772-06-3 C₁₈H₂₂N₄O₂ 
• 1174283-09-0 N-(2-(2-(1-tert-butyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,4,6-tetramethylbenzenesulfonamide 
• 1174282-70-2 4-methoxy-N,2,3,6-tetramethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide 
• 1174283-11-4 N,2,4,6-tetramethyl-N-(2-(2-oxo-2-(1-(pyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)ethoxy)ethyl)benzenesulfonamide 
• 1174282-63-3 N-(2-(2-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethoxy)ethyl)-N-isobutyl-4-methoxy-2,3,6-trimethylbenzenesulfonamide 
• 1174282-88-2 N-benzyl-4-methoxy-2,6-dimethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide 
• 1174283-17-0 N-(2-(2-(1-(3-fluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,4,6-tetramethylbenzenesulfonamide 
• 1174282-82-6 N-benzyl-4-methoxy-2,3,6-trimethyl-N-(2-(2-(1-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)benzenesulfonamide 
• 1174283-06-7 4-methoxy-N-(2-(2-(1-(3-methoxyphenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-N,2,6-trimethylbenzenesulfonamide 
• 1174282-85-9 N-benzyl-N-(2-(2-(5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,3,6-trimethylbenzenesulfonamide 
• 1174282-72-4 N-(2-(2-(1-(6-chloropyridin-3-yl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,3,6-tetramethylbenzenesulfonamide 
• 1174283-01-2 N-(2-(2-(1-(3,4-difluorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-oxoethoxy)ethyl)-4-methoxy-N,2,6-trimethylbenzenesulfonamide 

Relevant articles and documents

1,2,3,6-Tetrahydropyrrolo[1,2-d][1,4]diazocines. Reactions of 1-methyl-2-R-tetrahydropyrrolo[1,2-a]pyrazines with alkynes

The reactions of 6-formyl-and 6-trifluoroacetyl-1-methyl-2-R- tetrahydropyrrolo[1,2-a]- pyrazines with activated alkynes in methanol and acetonitrile have been studied. Terahydro- pyrrolo[1,2-d][1,4]diazocine derivatives were synthesized at the first time.

Substituted Sulfonamide Compounds

Substituted sulfonamide compounds corresponding to the formula I wherein m, n, p, Q, R1, R2, R3, R4, X, Y and Z have the respective meanings defined herein, pharmaceutical compositions containing such compounds, a process for their preparation, and the use of such compounds for the treatment and/or inhibition of pain and other conditions mediated by bradykinin receptor 1 (B1R) and/or bradykinin receptor 2 (B2R).

SUBSTITUTED SULFONAMIDE DERIVATIVES

The invention relates to substituted sulfonamide derivatives of the general formula (I'); processes for their preparation, medicaments containing these compounds, and the use of substituted sulfonamide derivatives for the preparation of medicaments

Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain

Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 K+ channels.

AZACYCLOALKANES. XXIX. SYNTHESIS OF 1-SUBSTITUTED 3,4-DIHYDROPYRROLOPYRAZINES

The reaction of 2-acylfurans with ethylenediamine is a general method for the production of 1-substituted 3,4-dihydropyrrolopyrazines.