73672-37-4

Usage

Uses

Used in Organic Synthesis:
3-Pyridineacetic acid, α-oxo, ethyl ester is used as a building block in the synthesis of various pharmaceuticals and agrochemicals for its versatile chemical properties and reactivity.
Used in Pharmaceutical Industry:
3-Pyridineacetic acid, α-oxo, ethyl ester is used as an intermediate in the production of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
3-Pyridineacetic acid, α-oxo, ethyl ester is used as a precursor in the synthesis of agrochemicals, aiding in the creation of pesticides and other agricultural products.
Used in Chemical Industry as a Solvent:
3-Pyridineacetic acid, α-oxo, ethyl ester is utilized as a solvent in various chemical processes due to its ability to dissolve a wide range of substances.
Used in Food Industry as a Flavoring Ingredient:
3-Pyridineacetic acid, α-oxo, ethyl ester is employed as a flavoring ingredient in the food industry, enhancing the taste and aroma of certain products while being mindful of its potential harmful effects if not handled properly.

InChI:InChI=1/C9H9NO3/c1-2-13-9(12)8(11)7-4-3-5-10-6-7/h3-6H,2H2,1H3

Upstream product

• 59020-10-9 3-(tributylstannyl)pyridine 
• 4755-77-5 Ethyl oxalyl chloride 
• 626-55-1 3-Bromopyridine 
• 109-72-8 n-butyllithium 
• 95-92-1 oxalic acid diethyl ester 
• 850535-74-9 ethyl 4-cyano-1-methoxymethyl-1,4-dihydro-3-pyridineglyoxylate 
• 110-86-1 pyridine 
• 39684-37-2 oxopyridin-3-ylacetic acid 
• 64-17-5 ethanol 
• 45706-16-9 1-methoxymethyl-pyridinium 
• 6221-12-1 3-Bromoacetylpyridine 
• 51364-84-2 1-Methoxymethyl-1,4-dihydro-pyridine-4-carbonitrile 

Downstream Products

• 1431323-27-1 (+)-(R)-ethyl 2-hydroxy-3-oxo-5-phenyl-2-(pyridin-3-yl)pentanoate 
• 250601-34-4 E-2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-2-(pyridine-1-oxide-3-yl)acetic acid 
• 250601-30-0 ethyl E-2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-2-(pyridin-3-yl)acetate 

Relevant academic research and scientific papers

Highly chemo- and enantioselective cross-benzoin reaction of aliphatic aldehydes and α-ketoesters

An electron-deficient, valine-derived triazolium salt is shown to catalyze a highly chemo- and enantioselective cross-benzoin reaction between aliphatic aldehydes and α-ketoesters. This methodology represents the first high yielding and highly enantioselective intermolecular cross-benzoin reaction using an organocatalyst (up to 94% ee). Further diastereoselective reduction of the products gives access to densely oxygenated compounds with high chemo- and diastereoselectivity.

AMINOPYRIDOPYRAZINONE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES

Aminopyridopyrazinone derivatives useful in treating disorders that are mediated by adenosine receptor function, including neurodegenerative diseases and inflammation, are disclosed. Pharmaceutical compositions, methods of treatment and use, involving the disclosed compounds, are also disclosed.

Activation of pyridinium salts for electrophilic acylation: A method for conversion of pyridines into 3-acylpyridines

Cyanide adducts of N-MOM pyridinium salts react with strong acylating reagents to provide 3-acyl-4-cyano-1,4-dihydropyridines that can be aromatized to 3-acylpyridines using ZnCl2 in refluxing ethanol.

Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity

This invention provides a novel oxyiminoalkanoic acid derivative which has excellent hypoglycemic and hypolipidemic actions and which is used for the treatment of diabetes mellitus, hyperlipemia, insulin insensitivity, insulin resistance and impaired glucose tolerance.

COUPLING OF ORGANOTIN REAGENTS WITH ARYL, ACYL AND HETEROARYL HALIDES: SYNTHESIS OF PYRIDAZINE AND QUINOXALONE DERIVATIVES

Couplin of organotin reagents Bu3SnAr (Ar = 2- or 3-thienyl, 2- or 3-pyridyl) with ClCOCH2CH2CO2Et in the presence of PdCl(CH2Ph)(PPh3)2 yields β-ketoesters ArCOCH2CH2CO2Et which were converted with hydrazine hydrate into 6-substituted 4,5-dihydropyridazin-3(2H)-ones, and thence to 3-halogeno-6-substituted pyridazines.The latter also couple under similar conditions with Bu3SnAr to yield 3-heteroarylpyridazines.With catalysts, coupling of ClCOCO2Et and Bu3SnAr proceeds with loss of carbon monoxide giving ArCO2Et, but without catalyst ArCOCO2Et is formed from which the3-heteroarylquinoxalin-3-one is prepared.The reactions of Bu3SnAr with 4-XC6H4Br (X = H,-OMe, -CN, -NO2) are also described.