73673-27-5Relevant academic research and scientific papers
Syntheses of polyalkylated imidazoles
Evjen, Sigvart,Fiksdahl, Anne
supporting information, p. 1392 - 1399 (2017/07/25)
We have developed improved general simple methods for large-scale preparation of polyalkylated imidazoles by improved multicomponent synthesis from commercially available starting materials. A large range of NH- and N-alkyl-polyalkylimidazoles (40 in total, including novel compounds) has been synthesized.
Synthesis of 4,5-substituted imidazoles by a fast condensation of 1,2-diketones and urotropine in heterogeneous medium
Bratulescu, George
experimental part, p. 2319 - 2320 (2010/02/28)
Starting from 1,2-diketones and urotropine in the presence of ammonium acetate, a simple and efficient solventless microwave-assisted synthesis of 4,5-disubstituted imidazoles was accomplished. Georg Thieme Verlag Stuttgart.
A Two-Step Synthesis of Imidazoles from Aldehydes via 4-Tosyloxazolines
Horne, David A.,Yakushijin, Kenichi,Buechi, George
, p. 139 - 154 (2007/10/02)
Imidazoles with substituents in the 4- and 4,5-positions were prepared by heating 4-tosyloxazolines in saturated methanolic ammonia.Similar treatment of these oxazolines with monoalkylamines regioselectively affords 1,4-disubstituted imidazoles.When oxazolines bearing an ethyl group at the 4-position were heated with alkylamines, however, a regioisomeric mixture of di- or trisubstituted imidazoles was produced.These reactions proceed via an intermolecular condensation of α-amino ketones and amidines or intramolecular cyclization of α-amidino ketone intermediates, respectively.
