4984-85-4Relevant academic research and scientific papers
Reaction of dialkylmagnesium with carbon monoxide. II
Sobota, Piotr,Nowak, Marek
, p. 1 - 6 (1988)
Reaction of MgEt2 with CO gives Et2CO, Et2CHOH, EtCOCH(OH)Et, EtCOCHEt2 and EtCOC(OH)Et2.The qualitative and quantitative composition of the product mixture was found to be dependent on the MgEt2 concentration and the polarity of solvent.The kinetic results reveal that reaction of CO with MgEt2 and with its dissociation product MgEt3-, followed by the formation of the Et2CO and EtCOCHEt2, respectively.The other compounds are formed in the subsequent reactions.The rate constants of formation of pentanone-3 and 4-ethylhexanone-3 are equal k1 0.292 s-1 and k2 0.450 s-1, respectively.
Simple method for selective oxidation of 1,2-diols in water with KBrO3/KHSO4
William, Julius M.,Kuriyama, Masami,Onomura, Osamu
, p. 6589 - 6592 (2014)
Readily available off-the-shelf KBrO3 and KHSO4 have been used to selectively oxidize 1,2-diols in water as a solvent. Various cyclic 1,2-diols have been tolerated affording their corresponding α-hydroxy ketones in good yields.
Development of Imidazoline-2-one Derivatives as Potential Antifungal and Anthelminthic Agents: in silico and in vitro Evaluation
Chilamakuru, Naresh Babu,Mallela, Vijaya Jyothi,Peraman, Ramalingam,Shaik, Shakir Basha,Simham, Venu,Singirisetty, Triveni
, p. 423 - 433 (2021/11/24)
Based on appropriate values of synthetic accessibility concerning from ADMET properties and docking scores by docking against proteins 3OZU and 1OJ0, a series of 4,5-diphenyl-1H-imidazol-2-ones (I1?15) were synthesized. The key intermediate, 2-hydroxy-1,2-disubstitutedethanones (E1?15) were prepared by benzoin condensation using 2:1 ratio of aromatic aldehydes and thiamine in the presence of alkali. Further, these cyclized ethanones (E1?15) were treated with urea to yield 4,5-diphenyl-1H-imidazol-2-one derivatives (I1?15) and were characterized by IR,1H NMR, Mass spectra, and CHNO analysis. The synthesized compounds were screened for their anthelmintic potential on Pheretima Posthuma along with standard albendazole, and antifungal activity (minimum inhibitory concentration method) on Candida albicans and Aspergillus niger along with standard miconazole. The results revealed that among all the tested compounds I3, I4, and I7 show considerable synthetic accessibility, docking scores, anthelminthic, and antifungal activity.
Sol-gel synthesis of ceria-zirconia-based high-entropy oxides as high-promotion catalysts for the synthesis of 1,2-diketones from aldehyde
Dinjar, Kristijan,Djerdj, Igor,Koj?inovi?, Jelena,Kukovecz, ákos,Markovi?, Berislav,Mileti?, Aleksandar,Nagy, Sándor Balázs,Sapi, Andras,Stenzel, David,Széchenyi, Aleksandar,Szenti, Imre,Tang, Yushu,Tatar, Dalibor,Varga, Gábor,Ziegenheim, Szilveszter
, (2021/10/20)
Efficient Lewis-acid-catalyzed direct conversion of aldehydes to 1,2-diketones in the liquid phase was enabled by using newly designed and developed ceria–zirconia-based high-entropy oxides (HEOs) as the actual catalysts. The synergistic effect of various cations incorporated in the same oxide structure (framework) was partially responsible for the efficiency of multicationic materials compared to the corresponding single-cation oxide forms. Furthermore, a clear, linear relationship between the Lewis acidity and the catalytic activity of the HEOs was observed. Due to the developed strategy, exclusively diketone-selective, recyclable, versatile heterogeneous catalytic transformation of aldehydes can be realized under mild reaction conditions.
Preparation Method for 2,3-pentanedione
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Paragraph 0018; 0019; 0024; 0025; 0029, (2019/04/25)
A preparation method for 2,3-pentanedione, including the steps of adding one or both of 3-hydroxy-2-pentanone and 2-hydroxy-3-pentanone into water and conducting mixing, and introducing ozone at the temperature of 3-20° C. for a reaction to obtain 2,3-pentanedione. The synthesis process of the present invention uses ozone for oxidizing a mixture containing 3-hydroxy-2-pentanone and 2-hydroxy-3-pentanone, acetic acid is used as a cocatalyst, reaction conditions are mild, the operation process is simple, the product yield is high, and the cost is low.
Preparation method of 2,3-pentanedione
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Paragraph 0004; 0017-0019; 0024-0026; 0031-0033, (2018/09/08)
The invention discloses a preparation method of 2,3-pentanedione. The preparation method comprises the following steps: one or two of 3-hydroxy-2-pentanone and 2-hydroxy-3-pentanone is/are added to water and uniformly mixed with water, ozone is introduced at the temperature of 3-20 DEG C for a reaction, and 2,3-pentanedione is obtained. According to the synthesis process, ozone is adopted to oxidize the mixture containing 3-hydroxy-2-pentanone and 2-hydroxy-3-pentanone, acetic acid is adopted as a cocatalyst, reaction conditions are mild, and operation process is simple; product yield is high;cost is low; the method has the advantages of being safe and environmentally friendly, and no wastewater is produced.
Synthesizing method of 3,4-heptadione
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Paragraph 0018; 0027; 0031; 0035, (2017/09/18)
The invention provides a synthesizing method of 3,4-heptadione. The synthesizing method comprises the following steps of (1) using propionaldehyde and butyraldehyde as raw materials, adding a main catalyst, and reacting under the alkaline condition, so as to synthesize 4-hydroxyl-3-heptanone; (2) mixing the 4-hydroxyl-3-heptanone, sulfuric acid and an oxidant to oxidize, so as to obtain the 3,4-heptadione. The synthesizing method of the 3,4-heptadione has the advantages that the main raw materials are the propionaldehyde and butyraldehyde, the obtaining of the raw materials is easy, the cost is low, and the production cost is reduced.
Preparation method of acyloin compounds
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Paragraph 0018; 0019; 0021; 0022, (2017/08/27)
The invention relates to a preparation method of acyloin compounds, and belongs to the field of fine chemical industry. A new catalyst 1-n butyl benzimidazole hydrochloride is provided for synthesis of the acyloin compounds, and the products have the advantages of good quality and less side reactions; deficiencies existed in the prior art are overcome.
Regio- and Stereoselective Aliphatic–Aromatic Cross-Benzoin Reaction: Enzymatic Divergent Catalysis
Beigi, Maryam,Gauchenova, Ekaterina,Walter, Lydia,Waltzer, Simon,Bonina, Fabrizio,Stillger, Thomas,Rother, D?rte,Pohl, Martina,Müller, Michael
supporting information, p. 13999 - 14005 (2016/09/21)
The catalytic asymmetric synthesis of chiral 2-hydroxy ketones by using different thiamine diphosphate dependent enzymes, namely benzaldehyde lyase from Pseudomonas fluorescens (PfBAL), a variant of benzoylformate decarboxylase from?Pseudomonas putida (PpBFD-L461A), branched-chain 2-keto acid decarboxylase from Lactococcus lactis (LlKdcA) and a variant of pyruvate decarboxylase from Acetobacter pasteurianus (ApPDC-E469G), was studied. Starting with the same set of substrates, substituted benzaldehydes in combination with different aliphatic aldehydes, PfBAL and PpBFD-L461A selectively deliver the (R)- and (S)-2-hydroxy-propiophenone derivatives, respectively. The (R)- and (S)-phenylacetylcarbinol (1-hydroxy-1-phenylacetone) derivatives are accessible in a similar way using LlKdcA and ApPDC-E469G, respectively. In many cases excellent stereochemical purities (>98 % enantiomeric excess) could be achieved. Hence, the regio- and stereochemistry of the product in the asymmetric aliphatic–aromatic cross-benzoin reaction can be controlled solely by choice of the appropriate enzyme or enzyme variant.
Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones
Dong, Kaiwu,Sang, Rui,Soule, Jean-Francois,Bruneau, Christian,Franke, Robert,Jackstell, Ralf,Beller, Matthias
supporting information, p. 18033 - 18037 (2015/12/24)
An improved domino hydroformylation/benzoin condensation to give α-hydroxy ketones has been developed. Easily available olefins are smoothly converted into the corresponding α-hydroxy ketones in high yields with excellent regioselectivities. Key to success is the use of a specific catalytic system consisting of a rhodium/phosphine complex and the CO2 adduct of an N-heterocyclic carbene. 2 for 1: An improved domino hydroformylation/benzoin condensation of olefins has been developed in the presence of a specific catalytic system consisting of a rhodium/phosphine complex and the CO2 adduct of an N-heterocyclic carbene.
