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Trans-(cyclobutane-1,2-diyl)dimethanol, also known as 1,2-cyclobutanediol, is an organic compound with the molecular formula C4H8O2. It is a cyclic diol, featuring a four-membered cyclobutane ring with two hydroxyl groups attached to the 1 and 2 positions. trans-(cyclobutane-1,2-diyl)dimethanol is known for its unique ring structure and can be used as a building block in the synthesis of various organic compounds, including pharmaceuticals and polymers. Due to its strained ring system, it exhibits interesting chemical reactivity and can undergo ring-opening reactions to form new compounds. Trans-(cyclobutane-1,2-diyl)dimethanol is a colorless liquid with a sweet odor and is sensitive to air and light, requiring proper storage conditions to maintain its stability.

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  • 7371-64-4 Structure
  • Basic information

    1. Product Name: trans-(cyclobutane-1,2-diyl)dimethanol
    2. Synonyms:
    3. CAS NO:7371-64-4
    4. Molecular Formula:
    5. Molecular Weight: 116.16
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 7371-64-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: trans-(cyclobutane-1,2-diyl)dimethanol(CAS DataBase Reference)
    10. NIST Chemistry Reference: trans-(cyclobutane-1,2-diyl)dimethanol(7371-64-4)
    11. EPA Substance Registry System: trans-(cyclobutane-1,2-diyl)dimethanol(7371-64-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 7371-64-4(Hazardous Substances Data)

7371-64-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7371-64-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,7 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 7371-64:
(6*7)+(5*3)+(4*7)+(3*1)+(2*6)+(1*4)=104
104 % 10 = 4
So 7371-64-4 is a valid CAS Registry Number.

7371-64-4Relevant articles and documents

Understanding the Structure–Polymerization Thermodynamics Relationships of Fused-Ring Cyclooctenes for Developing Chemically Recyclable Polymers

Sathe, Devavrat,Wang, Junpeng,Zhou, Junfeng

, p. 928 - 934 (2022/01/19)

Polymers that can be chemically recycled to their constituent monomers offer a promising solution to address the challenges in plastics sustainability through a circular use of materials. The design and development of monomers for next-generation chemical

MACROCYCLIC SPIROETHERS AS MCL-1 INHIBITORS

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Paragraph 0747; 0749; 0750, (2020/07/31)

Provided are compounds represented by Formula (I-A) and the pharmaceutically acceptable salts and solvates thereof, wherein R8, R9a, R9b, R9c, R9d, X, Y, Z, Z1, W, and (aa) are as defined as set forth in the specification. Provided are also compounds of Formula (I-A) for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

Epimerization of Tertiary Carbon Centers via Reversible Radical Cleavage of Unactivated C(sp3)-H Bonds

Wang, Yaxin,Hu, Xiafei,Morales-Rivera, Cristian A.,Li, Guo-Xing,Huang, Xin,He, Gang,Liu, Peng,Chen, Gong

, p. 9678 - 9684 (2018/07/21)

Reversible cleavage of C(sp3)-H bonds can enable racemization or epimerization, offering a valuable tool to edit the stereochemistry of organic compounds. While epimerization reactions operating via cleavage of acidic C(sp3)-H bonds, such as the Cα-H of carbonyl compounds, have been widely used in organic synthesis and enzyme-catalyzed biosynthesis, epimerization of tertiary carbons bearing a nonacidic C(sp3)-H bond is much more challenging with few practical methods available. Herein, we report the first synthetically useful protocol for the epimerization of tertiary carbons via reversible radical cleavage of unactivated C(sp3)-H bonds with hypervalent iodine reagent benziodoxole azide and H2O under mild conditions. These reactions exhibit excellent reactivity and selectivity for unactivated 3° C-H bonds of various cycloalkanes and offer a powerful strategy for editing the stereochemical configurations of carbon scaffolds intractable to conventional methods. Mechanistic study suggests that the unique ability of N3? to serve as a catalytic H atom shuttle is critical to reversibly break and reform 3° C-H bonds with high efficiency and selectivity.

Enzymes in Organic Synthesis. 24. Preparations of Enantiomerically Pure Chiral Lactones via Stereospecific Horse Liver Alcohol Dehydrogenase Catalyzed Oxidations of Monocyclic Meso Diols

Jakovac, Ignac J.,Goodbrand, H. Bruce,Lok, Kar P.,Jones, J. Bryan

, p. 4659 - 4665 (2007/10/02)

Preparative-scale horse liver alcohol dehydrogenase catalyzed oxidation of monocyclic meso diols provides a direct and convenient one-step route to a broad range of chiral γ-lactones of value as synthons in asymmetric synthesis.The general applicability of the method is demonstrated by oxidations of cis-1,2-bis(hydroxymethyl) substrates of the cyclohexyl, cyclohexenyl, cyclopentyl, cyclobutyl, cyclopropyl, and dimethylcyclopropyl series.For each diol, oxidation of the hydroxymethyl group attached to the S chiral center occurs exclusively, and the pure γ-lactone products are isolated in high (68-90percent) yields and of 100percent ee.In contrast, the enzyme does not exhibit significant enantiomeric selectivity in its catalysis of oxidations of the corresponding racemic trans diols.The stereospecificities observed, or lack thereof, are as predicted by the active-site model.

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