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3396-14-3 Usage


Cyclobutane-1,2-dicarboxylic acid is an organic compound with the chemical formula C6H8O4. It features a cyclobutane core, which is a simple cyclic alkane structure, and two carboxylic acid groups at the 1 and 2 positions. These carboxylic acid groups contribute to its acidic nature. Due to its molecular structure, cyclobutane-1,2-dicarboxylic acid is commonly used in synthetic and organic chemistry as a fine chemical intermediate.


Used in Synthetic and Organic Chemistry:
Cyclobutane-1,2-dicarboxylic acid is used as a fine chemical intermediate for its role in the synthesis of various organic compounds. Its cyclobutane core and carboxylic acid groups make it a versatile building block in the creation of complex molecules.
Used in Pharmaceutical Industry:
Cyclobutane-1,2-dicarboxylic acid is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Material Science:
Cyclobutane-1,2-dicarboxylic acid is used as a monomer in the production of polymers and other materials. Its properties can be tailored to create materials with specific characteristics, such as strength, flexibility, or chemical resistance.

Check Digit Verification of cas no

The CAS Registry Mumber 3396-14-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,9 and 6 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 3396-14:
93 % 10 = 3
So 3396-14-3 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier

Product name 1,2-Cyclobutanedicarboxylic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3396-14-3 SDS

3396-14-3Relevant articles and documents

Novel synthesis method of lobaplatin intermediate


, (2021/09/22)

The invention relates to the technical field of drug synthesis, in particular to a novel synthesis method of a loxetine intermediate, which is coupled through low-toxicity dimethyl malonate as a starting raw material. The synthesis of high purity trans -1, 2 - dicyanocyclobutane is carried out after the reaction of bromination, cyclization, hydrolysis, amidation and dehydration. In addition, the yield of the product is greatly improved, so that the cost is greatly reduced, the obtained trans -1 and 2 -dicyanocyclobutane are improved in purity, the subsequent use requirements are completely met, and the market competitiveness is greatly improved.

The synthesis and use in asymmetric epoxidation of metal salen complexes derived from enantiopure trans-cyclopentane- and cyclobutane-1,2-diamine

Daly, Adrian M.,Gilheany, Declan G.

, p. 127 - 137 (2007/10/03)

A complete synthesis of enantiopure trans-cyclopentane-1,2-diamine and trans-cyclobutane-1,2-diamine is described. These diamines have been used as components of novel chiral salen ligands whose chromium and manganese complexes were then evaluated as oxygen transfer agents in the asymmetric epoxidation of alkenes.

Elimination and Addition Reactions. Part 43. Eliminative Fission of Cyclobutanes and the Relationship between Strain and Reactivity in Cyclobutanes and Cyclopropanes

Earl, Harold A.,Stirling, Charles J. M.

, p. 1273 - 1280 (2007/10/02)

Eliminative fission of cyclobutanes has been compared with that of analogous cyclopropanes; reactivity differences of 103.7-104.8 have been determined.In both sets of compounds, mechanisms have been shown to involve rate-determining ring fission.The possibilities that the large reactivity differences between the comparably strained systems are due either to peculiarity in the cyclobutane structures or to their abnormally slow deprotonation are rejected.Analysis of strain in the two systems suggests that as ring fission occurs, dispersal of the excess of enthalpy of the cyclobutanes is a less sensitive function of extension of a bond in the ring than for the cyclopropanes.The behaviour of these systems is compared with cleavage of cyclopropanes and cyclobutanes in other reactions; the results are remarkably similar.Calculations using the MINDO3 programme have been carried out for eliminative fissions of cyclopropylmethyl and cyclobutylmethyl carbanions.These reproduce remarkably closely the difference between the heats of formation of the species at the energy maxima for fission of each ring size; the maximum for fission of the cyclobutane is considerably displaced along the reaction co-ordinate towards product.

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