7374-99-4

Upstream product

• 94100-11-5 5-chloro-3-(2-methylphenyl)-2,1-benzisoxazole 
• 89-92-9 2-methylbenzyl bromide 
• 22364-68-7 2-tolylmethylnitrile 
• 869365-84-4 N-[4-chloro-2-(2-methyl-benzoyl)-phenyl]-benzamide 

Downstream Products

• 115435-80-8 2-amino-5-chloro-2'-methylbenzhydrol 
• 115103-01-0 7-chloro-5-(2-methylphenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione 
• 115435-83-1 8-chloro-6-(2-methylphenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 115435-86-4 8-chloro-6-(2-methylphenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 5358-35-0 7-chloro-5-(2-methylphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one 
• 23603-51-2 6-chloro-4-o-tolyl-1H-quinazolin-2-one 
• 136281-37-3 ethyl 6-chloro-1,2-dihydro-1-methyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate 
• 1026723-98-7 6-Chloro-3-isocyanato-1-methyl-4-o-tolyl-1H-quinolin-2-one 
• 136281-38-4 6-chloro-1,2-dihydro-1-methyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylic acid 
• 136281-36-2 ethyl 6-chloro-1,2-dihydro-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate 
• 115435-81-9 5-chloro-2'-methyl-2-(phthalimidoacetamido)benzophenone 

Relevant academic research and scientific papers

Compounds and methods for inhibiting mitotic progression

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat

Improved synthesis of 2-amino-5-chlorophenyl-2'-pyrrylketone, a key intermediate in the synthesis of HIV Tat-antagonists

The reaction of a 2-phenylbenzoxazinone with pyrryl Grignard reagent is very efficient compared with that of a 2-methylbenzoxazinone. The title compound was prepared from 5-chloroanthranilic acid via the 2-phenylbenzoxazinone in 92% overall yield. This method was also successfully applied to the synthesis of 2-aminobenzophenones.

REACTION OF 4-CHLORO-1-NITROBENZENE WITH o-SUBSTITUTED PHENYLACETONITRILES; SYNTHESIS OF 8-CHLORO-1-METHYL(AND METHYLTHIOMETHYL)-6-(2-SUBSTITUTED PHENYL)-4H-s-TRIAZOLO-1,4-BENZODIAZEPINES

Reactions of 4-chloro-1-nitrobenzene with 2-methyl-, 2-methoxy- and 2-(methylthio)phenylacetonitrile in methanolic potassium hydroxide gave mixture from which the excepted 3-aryl-5-chloro-2,1-benzisoxazoles Ia-c were isolated in addition to the 2H-indoles IIIa and IIIc and acridines VIII and IX.The 2,1-benzisoxazoles were reduced to the 2-aminobenzophenones XIIa-c which were transformed via the phthalimidoacetamido compounds XIIIa-c to 5-aryl-7-chloro-1,3-dihydro-1,4-benzodiazepine-2-ones XVa-c.Treatment with phosphorus pentasulfide led to the thiones XVIa-c which reacted in boiling butanol either with acetohydrazide or with (methylthio)acetohydrazide to give the title compounds XVIIa-c and XVIIIa-c.They showed only weak anticonvulsant, incoordinating and central depressant effects.