94100-11-5

Usage

Class

Benzisoxazoles

Derivative

2,1-Benzisoxazole

Role

Fluorescent probe for calcium ions

Usage

Biological and biochemical studies, monitoring changes in calcium levels within cells

Potential applications

Imaging and sensing technologies, neuroscience, and cell signaling research

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 22364-68-7 2-tolylmethylnitrile 
• 89-92-9 2-methylbenzyl bromide 

Downstream Products

• 115103-01-0 7-chloro-5-(2-methylphenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione 
• 115435-83-1 8-chloro-6-(2-methylphenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 115435-86-4 8-chloro-6-(2-methylphenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 115435-81-9 5-chloro-2'-methyl-2-(phthalimidoacetamido)benzophenone 
• 5358-35-0 7-chloro-5-(2-methylphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one 
• 7374-99-4 2-amino-5-chloro-2-methylbenzophenone 
• 115435-80-8 2-amino-5-chloro-2'-methylbenzhydrol 

Relevant academic research and scientific papers

REACTION OF 4-CHLORO-1-NITROBENZENE WITH o-SUBSTITUTED PHENYLACETONITRILES; SYNTHESIS OF 8-CHLORO-1-METHYL(AND METHYLTHIOMETHYL)-6-(2-SUBSTITUTED PHENYL)-4H-s-TRIAZOLO-1,4-BENZODIAZEPINES

Reactions of 4-chloro-1-nitrobenzene with 2-methyl-, 2-methoxy- and 2-(methylthio)phenylacetonitrile in methanolic potassium hydroxide gave mixture from which the excepted 3-aryl-5-chloro-2,1-benzisoxazoles Ia-c were isolated in addition to the 2H-indoles IIIa and IIIc and acridines VIII and IX.The 2,1-benzisoxazoles were reduced to the 2-aminobenzophenones XIIa-c which were transformed via the phthalimidoacetamido compounds XIIIa-c to 5-aryl-7-chloro-1,3-dihydro-1,4-benzodiazepine-2-ones XVa-c.Treatment with phosphorus pentasulfide led to the thiones XVIa-c which reacted in boiling butanol either with acetohydrazide or with (methylthio)acetohydrazide to give the title compounds XVIIa-c and XVIIIa-c.They showed only weak anticonvulsant, incoordinating and central depressant effects.