869365-84-4

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 7033-51-4 6-chloro-2-phenyl-benzo[d][1,3]oxazin-4-one 
• 33872-80-9 o-tolyl magnesium chloride 

Downstream Products

• 869365-86-6 N-[2-(2-bromomethylbenzoyl)-4-chlorophenyl]benzamide 
• 7374-99-4 2-amino-5-chloro-2-methylbenzophenone 

Relevant academic research and scientific papers

Improved synthesis of 2-amino-5-chlorophenyl-2'-pyrrylketone, a key intermediate in the synthesis of HIV Tat-antagonists

The reaction of a 2-phenylbenzoxazinone with pyrryl Grignard reagent is very efficient compared with that of a 2-methylbenzoxazinone. The title compound was prepared from 5-chloroanthranilic acid via the 2-phenylbenzoxazinone in 92% overall yield. This method was also successfully applied to the synthesis of 2-aminobenzophenones.

Compounds and methods for inhibiting mitotic progression

This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treat