73756-58-8

Upstream product

• 66051-14-7 (Z)-α-methyl-cinnamaldehyde 
• 34917-00-5 2-benzyl-2-methylmalonic acid 
• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 22436-06-2 2-methyl-3-phenylpropanol 

Downstream Products

• 85705-59-5 3-[4-(1,1-dimethylpentyl)-phenyl]-2-methylpropyl chloride 
• 855658-66-1 (2-methyl-3-phenyl-propyl)-malonic acid 
• 93273-41-7 4-methyl-5-phenylpentanoic acid 
• 24435-52-7 (2-methyl-3-phenyl-propyl)-malonic acid diethyl ester 

Relevant academic research and scientific papers

Syntheses and pharmacological activities of chiral fomocaines

The syntheses of two chiral fomocaines namely rac ({4-[2-methyl-3-(morpholin-4-yl)propyl]benzyl}-phenyl-ether (O/G 3) and rac {4-[1-methyl-3-(morpholin-4-yl)propyl]benzyl}-phenyl-ether) (O/G 5) are reported. These compounds are part of a new research program concerning the relation between chirality and local anaesthetic activity in the group of fomocaines. The yield over five steps is in the range of 9% (O/G 3) up to 19,2% (O/G 5). The racemates were resoluted via the diastereomeric salts formed with (+)- or (-)-camphersulfonic acid. The chromatographic resolution in analytical scale is successful using a Daicel OD-column. The enantiomers are stable. The surface anaesthesia of the racemates as well as of the enantiomeres is weaker in comparison with fomocaine. The rate of tissue irritation is higher. The LD50 (mouse i.v.) is in the range between 290-390 mg/kg, while fomocaine shows a LD50 value of 175 mg/kg.

Substituted phenylpropyl halides

A novel process for the preparation of phenylpropyl halides of the formula STR1 by reacting the corresponding phenylpropyl halides, substituted only by R2 and R1, with an alcohol, alkyl halide or olefin; and phenylpropyl halides wher