7377-03-9Relevant articles and documents
Influence of octanohydroxamic acid on the association behavior of cationic surfactants: Hydrolytic cleavage of phosphate ester
Satnami, Manmohan L.,Dewangan, Hitesh K.,Kandpal, Neha,Nagwanshi, Rekha,Ghosh, Kallol K.
, p. 805 - 814 (2016)
The surface properties and mixed micellization behavior of cetyltrimethylammonium bromide (CTAB), tetradecyltrimethylammonium bromide (TTAB) and dodecyltrimethylammonium bromide (DTAB) with octanohydroxamic acid (OHA) have been investigated by means of conductivity and surface tension measurements in aqueous solution and borate buffer at 300 K. The critical micelle concentration (cmc), surface properties such as maximum surface access (Γmax), surface pressure at the cmc (Πcmc) and minimum surface area per molecule (Amin) has been determined. The standard Gibbs free energy of micellization (ΔGm0), standard Gibbs free energy of adsorption (ΔGad0), and standard Gibbs free energy of micellization per alkyl chain (ΔGm,tail0) of cationic surfactant with OHA have been evaluated. The fluorescence quenching technique was used to estimate the aggregation number (Nagg) and packing parameter (P) for determining the structural feature of cationic surfactants in the presence of octanohydroxamic acid. The hydrolytic reaction of paraoxon with octanohydroxamic acid was studied under a cationic micellar system by using OHA- at 9.2 pH and 300 K. The variations of surface properties from aqueous medium to the reaction condition have also been discussed. Pseudophase model (PPM) has been fitted for the quantitative treatment of the data.
Preparation process of capryloyl hydroxamic acid
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Paragraph 0034-0042; 0046-0054, (2021/01/30)
The invention relates to the field of chemical synthesis, and particularly discloses a preparation process of capryloyl hydroxamic acid, which comprises the following steps: preparing ethyl n-caprylate, and preparing the capryloyl hydroxamic acid, wherein the ethyl n-caprylate is prepared by the following steps: mixing 1-1.5 kg of n-caprylic acid with 0.35-0.7 kg of ethanol, adding solid superacid, performing heating reflux for 5-7 hours, filtering to obtain precipitate and filtrate, and performing reduced pressure distillation on the filtrate to obtain the ethyl n-caprylate, and the obtainedprecipitate is washed and roasted to obtain the solid superacid, and the solid superacid is recycled to the preparation step of the ethyl n-caprylate for use. By using the solid superacid catalyst, the environmental friendliness of the esterification reaction in the n-capryloyl hydroxamic acid preparation process is improved.
Repurposing the 3-Isocyanobutanoic Acid Adenylation Enzyme SfaB for Versatile Amidation and Thioesterification
Zhu, Mengyi,Wang, Lijuan,He, Jing
supporting information, p. 2030 - 2035 (2020/11/30)
Genome mining of microbial natural products enables chemists not only to discover the bioactive molecules with novel skeletons, but also to identify the enzymes that catalyze diverse chemical reactions. Exploring the substrate promiscuity and catalytic mechanism of those biosynthetic enzymes facilitates the development of potential biocatalysts. SfaB is an acyl adenylate-forming enzyme that adenylates a unique building block, 3-isocyanobutanoic acid, in the biosynthetic pathway of the diisonitrile natural product SF2768 produced by Streptomyces thioluteus, and this AMP-ligase was demonstrated to accept a broad range of short-chain fatty acids (SCFAs). Herein, we repurpose SfaB to catalyze amidation or thioesterification between those SCFAs and various amine or thiol nucleophiles, thereby providing an alternative enzymatic approach to prepare the corresponding amides and thioesters in vitro.
