73790-02-0Relevant academic research and scientific papers
Visible Light-Promoted Phosphine-Catalyzed Difluoroalkylation of Arenes and Heterocycles
Lu, Heng,Wang, Dong-Yu,Zhang, Ao
, p. 942 - 951 (2020)
A visible light-promoted difluoroalkylation reaction of arenes or heterocycles, using triaryl phosphine as the catalyst and difluoroalkyl iodide as the alkylating agent, is presented. The strategy is highlighted by photocatalyst-free, mild reaction conditions and a broad substrate scope. Mechanistic experiments indicate that this reaction involves a radical-chain process that is initiated by an electron donor-acceptor complex formed from difluoroalkyl iodide and phosphine.
Silver-Mediated C–H Difluoromethylation of Arenes
Li, Jialiang,Wan, Wen,Ma, Guobin,Chen, Yunrong,Hu, Qingyang,Kang, Kai,Jiang, Haizhen,Hao, Jian
supporting information, p. 4916 - 4921 (2016/10/13)
The first AgI-mediated C–H ethoxycarbonyl difluoromethylation with TMSCF2COOEt (TMS = trimethylsilyl) has been developed. The radical difluoromethylation proceeds smoothly to give the difluoromethylated arenes in moderate to high yie
