73843-97-7Relevant academic research and scientific papers
Practical Synthesis of β-Ketothioesters by Acid-Catalyzed Hydrolysis of Ketene N,S-Acetals with Amino as the Leaving Group
Xu, Qi,Zheng, Baihui,Pan, Ling,Liu, Qun,Li, Yifei
, p. 3704 - 3710 (2019/06/14)
A Novel, general, and highly efficient methodology for the synthesis of β-ketothioesters from ketene N,S-acetals has been developed. In this acid-catalyzed reaction, the amino group, including both alkylamino and arylamino groups, of α-oxo ketene N,S-acetals can be easily displaced in the presence of H2O as nucleophile (hydrolysis) instead of the alkylthiol group reported. This new method is simple and practical. A series of β-ketothioesters were prepared in high yields with broad tolerance of substrates under mild reaction conditions.
Efficient synthesis of 6-amino-substituted pyridin-2(1H)-ones using in situ generated propiolic acid chloride
Schirok, Hartmut,Alonso-Alija, Cristina,Michels, Martin
, p. 3085 - 3094 (2007/10/03)
A regioselective and highly efficient synthesis of 6-amino-substituted pyridin-2(1H)-ones is presented. In situ generated propiolic acid chloride was used for the cyclization of acyclic β-keto N,S-acetals to afford the heterocyclic core. Substitution by a
