73902-65-5

Basic information

• Product Name: N2,3-DIMETHYL-1,2-BENZENEDIAMINE
• Synonyms: N2,3-DIMETHYL-1,2-BENZENEDIAMINE;N1,6-Dimethylbenzene-1,2-diamine
• CAS NO: 73902-65-5
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• Mol File: 73902-65-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N2,3-DIMETHYL-1,2-BENZENEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N2,3-DIMETHYL-1,2-BENZENEDIAMINE(73902-65-5)
• EPA Substance Registry System: N2,3-DIMETHYL-1,2-BENZENEDIAMINE(73902-65-5)

Safety Data

• Hazardous Substances Data: 73902-65-5(Hazardous Substances Data)

Usage

General Description

N2,3-Dimethyl-1,2-benzenediamine, also known as 3,6-Dimethyl-o-phenylenediamine, is an organic compound that belongs to the class of aromatic diamines. It is a derivative of benzene and contains two amino groups attached to the benzene ring. N2,3-DIMETHYL-1,2-BENZENEDIAMINE is commonly used in the production of synthetic polymers and dyes, as well as in the formulation of hair dyes and other cosmetic products. It is also utilized in the manufacturing of rubber and plastics. N2,3-Dimethyl-1,2-benzenediamine is classified as toxic if ingested or inhaled, and prolonged exposure to this chemical may cause irritation to the skin and eyes. Therefore, proper handling and safety precautions are necessary when working with this compound.

Upstream product

• 437-86-5 2-fluoro-3-nitrotoluene 
• 108-44-1 1-amino-3-methylbenzene 
• 3970-40-9 2-chloro-3-nitrotoluene 
• 70254-74-9 2,N-dimethyl-6-nitro-aniline 

Downstream Products

• 945021-49-8 C₉H₁₁N₃ 
• 17583-45-8 1,7-dimethyl-1H-benzo[d]imidazole 
• 1191924-14-7 C₂₂H₁₉Cl₂N₅ 
• 126990-86-1 1,8-Dimethyl-1,4-dihydro-quinoxaline-2,3-dione 

Relevant articles and documents

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action

In this report we describe 2-iminobenzimidazole (IBI) analogs, identified during the course of a phenotypic high-throughput screening campaign, as novel hepatitis C virus (HCV) inhibitors. A series of IBI derivatives was synthesized and evaluated for their inhibitory activity against infectious HCV. Among the IBIs derivatives studied in this work, we identified promising compounds with high antiviral efficacy, high selectivity index and good microsomal stability. Noteworthy, the IBI series exhibited inhibitory activity on early and late steps of the viral cycle, but not in the HCV replicon system demonstrating a mechanism of action distinct from clinical-stage and approved anti-HCV drugs. Overall, our results suggest that IBIs are predestinated for further exploration as lead compounds for novel HCV interventions.

Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3

High-throughput screening identified a low molecular weight antagonist of CXCR3 displaying micromolar activity in a membrane filtration-binding assay. Systematic modification of the benzimidazole core and tethered acetophenone moiety established tractable SAR of analogs with improved physicochemical properties and sub-micromolar activity across both human and murine receptors.