7403-65-8

Usage

Uses

Used in Chemical Analysis:
Ethyl 3-hydroxy-2,2,4-trimethyl-pentanoate is used as a biomarker in the analysis of the metabolic pathways of plasticizers, specifically for the plasticizer 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (T798120). Its detection in urine samples can help in understanding the body's response to exposure to this plasticizer and may be useful in toxicological studies.
Used in Environmental Monitoring:
In the Environmental Monitoring industry, ethyl 3-hydroxy-2,2,4-trimethyl-pentanoate is used as an indicator compound for assessing the presence and potential health risks of plasticizers in the environment. Monitoring its levels can provide insights into the exposure risks associated with the use of certain plasticizers and inform regulatory measures to protect public health.
Used in Pharmaceutical Research:
Ethyl 3-hydroxy-2,2,4-trimethyl-pentanoate may be used as a starting material or intermediate in the synthesis of novel pharmaceutical compounds. Its unique structural features could be exploited to develop new drugs with specific therapeutic applications, particularly if its metabolic properties can be harnessed for targeted drug delivery or enhanced bioavailability.
Used in Material Science:
In the Material Science industry, ethyl 3-hydroxy-2,2,4-trimethyl-pentanoate could be investigated for its potential use in the development of new polymers or as a component in the formulation of existing ones. Its chemical structure may offer specific advantages in terms of mechanical properties, durability, or biodegradability, which could be valuable in various applications, such as packaging materials or automotive components.

InChI:InChI=1/C10H20O3/c1-6-13-9(12)10(4,5)8(11)7(2)3/h7-8,11H,6H2,1-5H3

Upstream product

• 600-00-0 ethyl 2-bromoisobutyrate 
• 78-84-2 isobutyraldehyde 
• 31469-16-6 1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene 
• 97-62-1 Ethyl isobutyrate 
• 64-17-5 ethanol 
• 35763-45-2 2,2,4-trimethyl-3-hydroxyvaleric acid 
• 207446-12-6 2-dimethylsilanyl-2-methyl-propionic acid ethyl ester 

Downstream Products

• 5842-53-5 2,2,4-trimethyl-pent-3-en-1-ol 
• 5842-49-9 2,2,4-trimethyl-pent-3-enal 
• 3601-65-8 2,3,4-trimethyl-pentanal 
• 625-65-0 2,4-dimethyl-2-pentene 
• 144-19-4 2,2,4-trimethylpentan-1,3-diol 

Relevant academic research and scientific papers

Preparation method of 2, 2, 4-trimethyl-3-hydroxy ethyl valerate, water-based paint for containers and preparation method of water-based paint

The invention relates to the technical field of organic compound synthesis and application, in particular to a preparation method of 2, 2, 4-trimethyl-3-hydroxy ethyl valerate, a water-based paint containing 2, 2, 4-trimethyl-3-hydroxy ethyl valerate for containers and a preparation method of the water-based paint. The preparation method of 2, 2, 4-trimethyl-3-hydroxy ethyl valerate comprises thefollowing steps: 1) carrying out aldol condensation reaction on isobutyraldehyde under the action of a basic catalyst to generate 2, 2, 4-trimethyl-3-hydroxyvaleraldehyde, and carrying out oxidation reaction on the obtained 2, 2, 4-trimethyl-3-hydroxyvaleraldehyde and H2O2 to obtain 2, 2, 4-trimethyl-3-hydroxyvaleric acid; and 2) carrying out reaction on the 2, 2, 4-trimethyl-3-hydroxyvaleric acidprepared in the step 1) and ethanol under the action of a strong acid catalyst to obtain 2, 2, 4-trimethyl-3-hydroxy ethyl valerate. The preparation method of 2, 2, 4-trimethyl-3-hydroxy ethyl valerate has the advantages that the reaction product is single, multi-step separation is not needed, operation is simple, and meanwhile, the invention also provides the water-based paint containing 2, 2, 4-trimethyl-3-hydroxy ethyl valerate for containers and the preparation method of the water-based paint.

1,4-Bis(trimethylsilyl)-1,4-diaza-2,5-cyclohexadienes as strong salt-free reductants for generating low-valent early transition metals with electron-donating ligands

Electron-rich organosilicon compounds, such as 1,4-bis(trimethylsilyl)-1,4- diaza-2,5-cyclohexadiene (2a), 2,5-dimethyl-1,4-bis(trimethylsilyl)-1,4-diaza-2, 5-cyclohexadiene (2b), 2,3,5,6-tetramethyl-1,4-bis(trimethylsilyl)-1,4-diaza-2, 5-cyclohexadiene (

Metal chloride-promoted aldol reaction of α-dimethylsilylesters with aldehydes, ketones, and α-enones

In the presence of a catalytic amount of LiCl, α-dimethylsilylesters (α-DMS-esters) 1 smoothly reacted with various aldehydes at 30°C to give aldols in good to high yields. On the other hand, the aldol reaction with ketones was effectively promoted by MgCl2 rather than by LiCl. α-Enones also underwent the metal chloride-promoted addition of 1 at the carbonyl carbon or β-carbon. Georg Thieme Verlag Stuttgart.

Reformatsky Reaction in Water: Evidence for a Radical Chain Process

The Reformatsky reaction of 2-bromo esters and carbonyl compounds in the presence of zinc can be carried out in concentrated aqueous salt solutions without any cosolvent. The reaction of bromoacetates is greatly enhanced by catalytic amounts of benzoyl peroxide or peracids and gives satisfactory yields with aromatic aldehydes. Preparative yields comparable to those of the traditional procedure are obtained with ethyl 2-bromoisobutyrate. This ester needs no catalyst and reacts even with saturated aldehydes and aromatic ketones, although in low yields. A radical chain mechanism, initiated by electron abstraction from the organometallic Reformatsky reagent, is proposed. Two nonchain pathways, involving radicals directly produced on the metal surface, may compete, especially in the case of secondary and tertiary halides.

Boron Trifluoride Promoted Aldol Reaction of Silyl Ketene Acetals with the Intermediate Generated by the DIBALH Reduction of Carboxylic Acid Esters

The intermediate generated by the DIBALH reduction of carboxylic acid esters undergoes a boron trifluoride promoted aldol reaction with silyl ketene acetals to afford the corresponding β-hydroxy carboxylic acid esters in good yield.