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Ts-Phe-Gly-Pro is a tetrapeptide, a chain of four amino acids, consisting of Ts (O-tosyl-L-phenylalanine), Phe (phenylalanine), Gly (glycine), and Pro (proline). This specific sequence of amino acids is known for its role in certain biological processes and can be found in various peptides and proteins. The presence of Ts, a derivative of phenylalanine with a tosyl group, adds a unique chemical property to the peptide, potentially affecting its reactivity or stability. The sequence may be of interest in research related to peptide synthesis, drug development, or understanding protein structure and function.

74075-22-2

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74075-22-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 74075-22-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,0,7 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 74075-22:
(7*7)+(6*4)+(5*0)+(4*7)+(3*5)+(2*2)+(1*2)=122
122 % 10 = 2
So 74075-22-2 is a valid CAS Registry Number.

74075-22-2Downstream Products

74075-22-2Relevant academic research and scientific papers

Synthesis and biological activity of a ketomethylene analogue of a tripeptide inhibitor of angiotensin converting enzyme

Almquist,Chao,Ellis,Johnson

, p. 1392 - 1398 (2007/10/02)

An analogue of a tripeptide inhibitor of angiotensin converting enzyme, Bz-Phe-Gly-Pro, has been synthesized in which the amide bond connecting phenylalanine and glycine has been replaced by a ketomethylene group. This nonpeptide analogue, 20, shows more potent converting enzyme inhibiting activity, I50=0.07 μM, than Bz-Phe-Gly-Pro, I50=9.4 μM, or than the orally active D-3-mercapto-2-methylpropanoyl-L-proline (captopril, 1)I50=0.30 μM. Compound 20 has a K(i)of 1.06 x 10-7 and either competitive or noncompetitive enzyme kinetics depending on what substrate is used in the converting enzyme assay. In tests for inhibition of angiotensin I induced contractions in the guinea pig ileum, 20 has one-tenth the activity of 1.

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