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Ts-Phe-Gly-OEt, also known as Tosyl-Phe-Gly-Ethyl Ester, is a synthetic peptide compound consisting of three amino acids: phenylalanine (Phe), glycine (Gly), and an ethyl ester group (OEt). The phenylalanine is modified with a tosyl (Ts) group, which is a protecting group used in peptide synthesis to prevent unwanted side reactions. Ts-Phe-Gly-OEt is commonly used in the field of organic chemistry and peptide synthesis, particularly in the study of peptide bond formation and the development of new synthetic methods. Ts-Phe-Gly-OEt serves as a model compound for understanding the reactivity and stability of peptide bonds, as well as a building block for the synthesis of larger peptides and proteins.

35646-66-3

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35646-66-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 35646-66-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,6,4 and 6 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 35646-66:
(7*3)+(6*5)+(5*6)+(4*4)+(3*6)+(2*6)+(1*6)=133
133 % 10 = 3
So 35646-66-3 is a valid CAS Registry Number.

35646-66-3Relevant academic research and scientific papers

Synthesis and biological activity of a ketomethylene analogue of a tripeptide inhibitor of angiotensin converting enzyme

Almquist,Chao,Ellis,Johnson

, p. 1392 - 1398 (2007/10/02)

An analogue of a tripeptide inhibitor of angiotensin converting enzyme, Bz-Phe-Gly-Pro, has been synthesized in which the amide bond connecting phenylalanine and glycine has been replaced by a ketomethylene group. This nonpeptide analogue, 20, shows more potent converting enzyme inhibiting activity, I50=0.07 μM, than Bz-Phe-Gly-Pro, I50=9.4 μM, or than the orally active D-3-mercapto-2-methylpropanoyl-L-proline (captopril, 1)I50=0.30 μM. Compound 20 has a K(i)of 1.06 x 10-7 and either competitive or noncompetitive enzyme kinetics depending on what substrate is used in the converting enzyme assay. In tests for inhibition of angiotensin I induced contractions in the guinea pig ileum, 20 has one-tenth the activity of 1.

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