741693-89-0 Usage
Uses
Used in Pharmaceutical Industry:
5-Fluoro-2-Methoxy-1-naphthalenol is used as a reactant for the preparation of Duloxetine (D721000) metabolites. Duloxetine is a widely prescribed medication for the treatment of various conditions, including depression, anxiety, and neuropathic pain. 5-Fluoro-2-Methoxy-1-naphthalenol plays a crucial role in the synthesis of these metabolites, which are essential for understanding the drug's pharmacokinetics and pharmacodynamics.
Check Digit Verification of cas no
The CAS Registry Mumber 741693-89-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,1,6,9 and 3 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 741693-89:
(8*7)+(7*4)+(6*1)+(5*6)+(4*9)+(3*3)+(2*8)+(1*9)=190
190 % 10 = 0
So 741693-89-0 is a valid CAS Registry Number.
741693-89-0Relevant academic research and scientific papers
Synthesis and biological activity of some known and putative duloxetine metabolites
Kuo,Gillespie,Kulanthaivel,Lantz,Ma,Nelson,Threlkeld,Wheeler,Yi,Zmijewski
, p. 3481 - 3486 (2007/10/03)
Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine.
