853192-64-0 Usage
Uses
Used in Pharmaceutical Industry:
Naphthalene, 1-fluoro-6-methoxy(9CI) is used as a reactant in the preparation of Duloxetine metabolites. Duloxetine, with the CAS number D721000, is a medication primarily used to treat various mental health conditions, including depression, anxiety, and neuropathic pain. The synthesis of its metabolites is essential for understanding the drug's pharmacokinetics, efficacy, and potential side effects, ultimately contributing to the development and optimization of therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 853192-64-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,3,1,9 and 2 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 853192-64:
(8*8)+(7*5)+(6*3)+(5*1)+(4*9)+(3*2)+(2*6)+(1*4)=180
180 % 10 = 0
So 853192-64-0 is a valid CAS Registry Number.
853192-64-0Relevant academic research and scientific papers
ANTIPROLIFERATIVE BENZO [B] AZEPIN- 2 - ONES
-
, (2014/02/15)
Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R1, R2, R3 and R4 are described in this application, and methods of using said compounds in the treatment of cancer.
Synthesis and biological activity of some known and putative duloxetine metabolites
Kuo,Gillespie,Kulanthaivel,Lantz,Ma,Nelson,Threlkeld,Wheeler,Yi,Zmijewski
, p. 3481 - 3486 (2007/10/03)
Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine.
