74173-76-5

Basic information

• Product Name: 2,4-DICHLORO-6-IODOQUINAZOLINE
• Synonyms: 2,4-DICHLORO-6-IODOQUINAZOLINE;6-IODO-2,4-DICHLOROQUINAZOLINE;Quinazoline,2,4-dichloro-6-iodo-
• CAS NO: 74173-76-5
• Molecular Formula: C₈H₃Cl₂IN₂
• Molecular Weight: 324.93329
• Mol File: 74173-76-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 164-165 °C
• Boiling Point: 353.266°C at 760 mmHg
• Flash Point: 167.45°C
• Appearance: /
• Density: 2.083g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.741
• Storage Temp.: 2-8°C
• PKA: -1.11±0.30(Predicted)
• CAS DataBase Reference: 2,4-DICHLORO-6-IODOQUINAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-6-IODOQUINAZOLINE(74173-76-5)
• EPA Substance Registry System: 2,4-DICHLORO-6-IODOQUINAZOLINE(74173-76-5)

Safety Data

• Hazardous Substances Data: 74173-76-5(Hazardous Substances Data)

Usage

General Description

2,4-Dichloro-6-iodoquinazoline is a chemical compound that belongs to the quinazoline family. It is a heterocyclic organic compound that contains two chlorine atoms and one iodine atom. 2,4-DICHLORO-6-IODOQUINAZOLINE is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its chemical structure and reactivity make it a versatile intermediate in the production of a wide range of compounds. Additionally, its unique properties and reactivity make it useful for various research and development purposes in the fields of medicinal chemistry and drug discovery.

InChI:InChI=1/C8H3Cl2IN2/c9-7-5-3-4(11)1-2-6(5)12-8(10)13-7/h1-3H

Upstream product

• 16353-27-8 6-Iodo-1H-quinazoline-2,4-dione 
• 685866-85-7 6-iodo-quinazoline-2,4-diol sodium salt 
• 116027-11-3 N-<4-iodo-2-(methoxycarbonyl)phenyl>urea 
• 77317-55-6 methyl 2-amino-5-iodobenzoate 
• 116027-10-2 5-iodoisatoic anhydride 
• 5326-47-6 2-amino-5-iodobenzoic acid 
• 540-37-4 p-aminoiodobenzene 
• 533-70-0 2,4-diiodoaniline 
• 878133-06-3 N-(2,4-diiodo-phenyl)-2,2,2-trifluoro-acetamide 
• 132131-24-9 5-iodoanthranilonitrile 
• 503-38-8 trichloromethyl chloroformate 

Downstream Products

• 830343-17-4 [(2R,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(2,4-dimethoxy-quinazolin-6-yl)-2,5-dihydro-furan-2-yl]-methanol 
• 830343-27-6 6-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-1H-quinazoline-2,4-dione 
• 116027-13-5 ethyl (2-chloro-6-iodo-3,4-dihydroquinazolin-3-yl)acetate 
• 108857-18-7 7-iodo-1,2,3,5-tetrahydroimidazo<2,1-b>quinazolin-2(1H)-one 
• 830343-15-2 6-iodo-2,4-dimethoxyquinazoline 

Relevant articles and documents

Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors

A series of thiazoloquin(az)olinones were synthesized and found to have potent inhibitory activity against CD38. Several of these compounds were also shown to have good pharmacokinetic properties and demonstrated the ability to elevate NAD levels in plasm

Quinazolines and related heterocyclic compounds and their therapeutic use

A compound of the formula wherein X is CR1 or N; Y is CR3 or N; R1, R3, R4, R5 and R6 are independently H, F, Cl, Br, I, or a hydrocarbon group which optionally contains one or more heteroatoms; R7 is a heterocyclic group including one or more N atoms; R' is Rx or NRyRz wherein Rx, Ry and Rz are each H or the same or different groups, including cyclic groups formed by Ry and Rz with the N atom, of up to 20 C atoms and optionally including up to 3 further heteroatoms selected from N, O and S; or a pharmaceutically acceptable salt, ester or solvate thereof, has therapeutic utility.

Acetonitrile-mediated synthesis of 2,4-dichloroquinoline from 2-ethynylaniline and 2,4-dichloroquinazoline from anthranilonitrile

2,4-Dichloroquinolines and 2,4-dichloroquinazolines were synthesized from 2-ethynylanilines and anthranilonitriles, respectively, using diphosgene in acetonitrile and heating at 130 °C or 150 °C for 12 hours. This reaction was applied to the synthesis of 4,6-dichloropyrazolo[3,4-d]pyrimidine (dichloro-9H-isopurine). The postulated mechanism is also described. Georg Thieme Verlag Stuttgart.