7418-39-5Relevant academic research and scientific papers
Method for preparing N,N-diarylamide derivatives
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Paragraph 0040-0042, (2019/02/04)
The invention provides a method for preparing N,N-diarylamide derivatives and belongs to the technical field of chemical synthesis. The method comprises the following steps: taking N-arylamide and phenylboronic acid as raw materials, stirring in an organic solvent under blue light irradiation for 30-44 hours so as to obtain crude N,N-diarylamide, extracting and washing the crude product, and performing column chromatography isolation, thereby obtaining the high-purity N,N-diarylamide derivative. The method disclosed by the invention is simple and readily available in raw materials, mild in reaction condition and simple in operation, and the N,N-diarylamide derivatives with structural diversity can be easily obtained by changing the structures of the raw materials and have excellent application and market value.
Synthesis and conformational analysis of N-aryl-N-(3-thienyl)acetamides
Ito, Ai,Asami, Yuki,Asato, Marino,Fukuda, Kazuo,Yamasaki, Ryu,Okamoto, Iwao
, p. 2454 - 2458 (2018/05/25)
The cis-trans conformational equilibrium of amides is of interest because it can be used to control functional activity. Here, we designed and synthesized a series of N-(3-thienyl)amides in order to study the factors affecting their conformational equilibrium. NMR studies showed that the major conformer of N-methyl-N-(3-thienyl)amide in solution is the E-form (cis form), as is the case for N-methylacetamide. For N-aryl-N-(3-thienyl)amides bearing an N-phenyl moiety, the major conformers differ depending on not only the relative π-electron density of the N-aryl moiety, but also its size. X-ray analysis showed that their solid-state conformational preferences were similar to those in solution.
Metal-free n -arylation of secondary amides at room temperature
Tinnis, Fredrik,Stridfeldt, Elin,Lundberg, Helena,Adolfsson, Hans,Olofsson, Berit
, p. 2688 - 2691 (2015/06/16)
The arylation of secondary acyclic amides has been achieved with diaryliodonium salts under mild and metal-free conditions. The methodology has a wide scope, allows synthesis of tertiary amides with highly congested aryl moieties, and avoids the regioselectivity problems observed in reactions with (diacetoxyiodo)benzene.
Magnetically recyclable magnetite-palladium (Nanocat-Fe-Pd) nanocatalyst for the Buchwald-Hartwig reaction
Sa, Sofia,Gawande, Manoj B.,Velhinho, Alexandre,Veiga, Joao Pedro,Bundaleski, Nenad,Trigueiro, Joao,Tolstogouzov, Alexander,Teodoro, Orlando M. N. D.,Zboril, Radek,Varma, Rajender S.,Branco, Paula S.
, p. 3494 - 3500 (2014/07/08)
The immobilization of Pd on the magnetite surface afforded Nanocat-Fe-Pd using inexpensive precursors and its catalytic role in the Buchwald-Hartwig reaction for arylation of amines and amides was investigated; C-N bond formation was achieved in moderate to excellent yields and the catalyst could be separated and recycled up to five cycles by magnetic decantation without a significant loss in yield. This journal is the Partner Organisations 2014.
Oxidative rearrangement of ketimines to amides by MCPBA and BF3·OEt2
Kim, So Yeon,An, Gwang-Il,Rhee, Hakjune
, p. 112 - 114 (2007/10/03)
Several amides were obtained by an efficient method from the corresponding alkyl aryl ketimines in high yields. Ketimines are readily prepared from the corresponding ketones. This procedure involves the oxidation of alkyl aryl ketimines with MCPBA with BF3·OEt2. In this reaction, only aryl group of alkyl aryl ketimines was migrated to the electron deficient nitrogen atom.
Condensations of 1,4-Cyclohexanediones and Secondary Aromatic Amines. II. N-Phenylation of Diarylamines
Haga, Kazuo,Iwaya, Katsumasa,Kaneko, Ryohei
, p. 803 - 808 (2007/10/02)
The condensations of 1,4-cyclohexanedione with several diphenylamines were investigated in order to determine the limit of the utility of this reaction for the N-phenylation of aromatic secondary amines. 4-Methoxy-, 4,4'-dimethyl-, and 4,4'-dibromodiphenylamines produced their N-phenylated compounds in fairly good yields, but 4-hydroxy-, 3-methoxy-, and 4,4'-bis(dimethylamino)diphenylamines produced poor yields.Nitro-substituted diphenylamines gave N-phenyl derivatives in low yields along with N-4-hydroxyphenyl derivatives.N,N'-Diphenyl-p-phenylenediamine and N,N'-diphenylbenzidine gave correspondig tetra-N-phenyl diamines in good yields.The condensation of N-phenyl-1-naphthylamine, N-phenyl-2-naphthylamine, di-2-pyridylamine, phenothiazine, and carbazole with 1,4-cyclohexanedione were also examined.
