7425-79-8Relevant academic research and scientific papers
Structure-activity relationships of bisphenol a analogs at estrogen receptors (ERs): Discovery of an ERα-selective antagonist
Maruyama, Keisuke,Nakamura, Masaharu,Tomoshige, Shusuke,Sugita, Kazuyuki,Makishima, Makoto,Hashimoto, Yuichi,Ishikawa, Minoru
, p. 4031 - 4036 (2013/07/19)
Our multi-template approach for drug discovery, focusing on protein targets with similar fold structures, has yielded lead compounds for various targets. We have also shown that a diphenylmethane skeleton can serve as a surrogate for a steroid skeleton. H
3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1
Hosoda, Shinnosuke,Hashimoto, Yuichi
, p. 5414 - 5418 (2008/02/13)
We designed and synthesized novel type 1 5α-reductase inhibitors by using 3,3-diphenylpentane skeleton as a substitute for the usual steroid skeleton. 4-(3-(4-(N-Methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate (11k) is a competitive 5α-reductase inhibitor with the IC50 value of 0.84 μM.
Carbazole compounds
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, (2008/06/13)
A composition comprising an aromatic copolyestercarbonate having flexural modulus, flexural yield and secondary transition temperature improvement over a corresponding aromatic polycarbonate effective amount of ester units of the structure STR1 or mixtures of the above two structures wherein R1 and R2 are the same or different and are alkyl of one to six carbon atoms, inclusive, cycloalkyl of four to seven carbon atoms, inclusive, phenyl, one to three alkyl substituted phenyl each alkyl having one to three carbon atoms, inclusive, and R1 and R2 taken together with the nitrogen to which they are attached form a ring of four to six carbon atoms, inclusive, or carbazole.
