74254-13-0Relevant articles and documents
Nickel-Catalyzed Cyanation of Unactivated Alkyl Sulfonates with Zn(CN)2
Xia, Aiyou,Lv, Peizhuo,Xie, Xin,Liu, Yuanhong
, p. 7842 - 7847 (2020/11/02)
Cyanation of unactivated primary and secondary alkyl mesylates with Zn(CN)2 catalyzed by nickel has been developed. The reaction provides an efficient route for the synthesis of alkyl nitriles with wide substrate scope, good functional group tolerance, and compatibility with heterocyclic compounds. Mechanistic studies indicate that alkyl iodide generated in situ serves as the reactive intermediate and the gradual release of alkyl iodide is crucial for the success of the reaction.
Shifting Chemical Equilibria in Flow - Efficient Decarbonylation Driven by Annular Flow Regimes
Gutmann, Bernhard,Elsner, Petteri,Glasnov, Toma,Roberge, Dominique M.,Kappe, C. Oliver
supporting information, p. 11557 - 11561 (2016/02/19)
To efficiently drive chemical reactions, it is often necessary to influence an equilibrium by removing one or more components from the reaction space. Such manipulation is straightforward in open systems, for example, by distillation of a volatile product from the reaction mixture. Herein we describe a unique high-temperature/high-pressure gas/liquid continuous-flow process for the rhodium-catalyzed decarbonylation of aldehydes. The carbon monoxide released during the reaction is carried with a stream of an inert gas through the center of the tubing, whereas the liquid feed travels as an annular film along the wall of the channel. As a consequence, carbon monoxide is effectively vaporized from the liquid phase into the gas phase and stripped from the reaction mixture, thus driving the equilibrium to the product and preventing poisoning of the catalyst. This approach enables the catalytic decarbonylation of a variety of aldehydes with unprecedented efficiency with a standard coil-based flow device.
Iron-catalyzed decarboxylative methylation of α,β-unsaturated acids under ligand-free conditions
Rong, Guangwei,Liu, Defu,Lu, Linhua,Yan, Hong,Zheng, Yang,Chen, Jie,Mao, Jincheng
, p. 5033 - 5037 (2014/07/08)
It is the first time to find that iron-catalyzed decarboxylative methylation of α,β-unsaturated acids could be performed in the absence of any ligands. During the reaction, the configuration of the double bond could be retained. It is noteworthy that di-t
