60484-66-4

Usage

Uses

Used in Pharmaceutical Industry:
4-N-PROPYLBENZONITRILE is used as an intermediate chemical for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing medications.
Used in Agrochemical Industry:
4-N-PROPYLBENZONITRILE is used as a precursor in the production of agrochemicals, such as pesticides and herbicides, to enhance crop protection and increase agricultural productivity.
Used in Organic Dyes Industry:
4-N-PROPYLBENZONITRILE is used as a key component in the synthesis of organic dyes, which are utilized in various applications, including textiles, plastics, and printing inks.
Used in Industrial Chemistry:
4-N-PROPYLBENZONITRILE is used as a versatile building block in the synthesis of various organic compounds, contributing to the advancement of industrial chemistry and the development of new materials and products.

InChI:InChI=1/C10H11N/c1-2-3-9-4-6-10(8-11)7-5-9/h4-7H,2-3H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 104-85-8 para-methylbenzonitrile 
• 105-07-7 4-cyanobenzaldehyde 
• 623-00-7 4-bromobenzenecarbonitrile 
• 1239384-16-7 [2-(2-hydroxyprop-2-yl)phenyl]triisopropylsilane 
• 77047-87-1 isopropyl zinc bromide 
• 28785-06-0 4-n-propylbenzaldehyde 
• 74254-13-0 (E)-4-(prop-1-en-1-yl)benzonitrile 
• 140675-27-0 (E/Z)-4-(prop-1-en-1-yl)benzonitrile 

Downstream Products

• 1595-09-1 1-methyl-4-n-pentylbenzene 
• 83805-09-8 4-pentylbenzyl 4-propylphenyl ketone 
• 29147-97-5 p-n-propylbenzamidinium chloride 

Relevant academic research and scientific papers

A Molecular Iron-Based System for Divergent Bond Activation: Controlling the Reactivity of Aldehydes

The direct synthesis of amides and nitriles from readily available aldehyde precursors provides access to functional groups of major synthetic utility. To date, most reliable catalytic methods have typically been optimized to supply one product exclusively. Herein, we describe an approach centered on an operationally simple iron-based system that, depending on the reaction conditions, selectively addresses either the C=O or C-H bond of aldehydes. This way, two divergent reaction pathways can be opened to furnish both products in high yields and selectivities under mild reaction conditions. The catalyst system takes advantage of iron's dual reactivity capable of acting as (1) a Lewis acid and (2) a nitrene transfer platform to govern the aldehyde building block. The present transformation offers a rare control over the selectivity on the basis of the iron system's ionic nature. This approach expands the repertoire of protocols for amide and nitrile synthesis and shows that fine adjustments of the catalyst system's molecular environment can supply control over bond activation processes, thus providing easy access to various products from primary building blocks.

Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd-PEPPSI-IPent

Pd-PEPPSI-IPent has proven to be an excellent catalyst for the Negishi cross-coupling reaction of secondary alkylzinc reagents with a wide variety of aryl/heteroaryl halides. Importantly, β-hydride elimination/migratory insertion of the organometallic leading to the production of isomeric coupling products has been significantly reduced using the highly-hindered Ipent ligand.

Cross-coupling reactions through the intramolecular activation of Alkyl(triorgano)silanes

(Figure Presented) Cross-Si-ing the Jordan: Cross-coupling reactions of 2-(2-hydroxyprop-2-yl)phenylsubstituted alkylsilanes with a variety of aryl halides proceed in the presence of palladium and copper catalysts. The use of K3PO4 base allows for highly chemoselective alkyl coupling with both primary and secondary alkyl groups (Alk).

Understanding binding affinity: A combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin

The binding of a series of p-alkylbenzamidinium chloride inhibitors to the serine proteinase trypsin over a range of temperatures has been studied using isothermal titration (micro)calorimetry and molecular dynamics simulation techniques. The inhibitors h

The action of sodium hydrogen telluride on olefins

The action of sodium hydrogen telluride, NaTeH, on non electrophilic carbon-arbon double bonds has been investigated.The reaction is found to be very sensitive to the substituents on the ethylenic linkage. Whereas phenyl conjugated olefins are reduced to alkylbenzenes,the reagent adds to isolated mono and disubstituted double bonds leading to organotellurium derivatives and with gem-disubstituted ones it leads to a mixture of reduction and addition products. These results are interpreted in terms of a radical pair mechanism involving hydrogen atom transfer from hydrogen telluride,HTe- to the double bond.

SODIUM HYDROGEN TELLURIDE: A MECHANISTIC CHAMELEON

Relative rates of reduction of several α,β-unsaturated esters and styrenes added to recently obtained results from other substrates show that sodium hydrogen telluride (NaTeH) can react according to different mechanisms : nucleophilic substitution, hydride transfer, hydrogen atom transfer and electron transfer.