74270-70-5

Usage

InChI:InChI=1/C14H14N4OS/c1-10-4-2-3-5-12(10)16-14(20)18-17-13(19)11-6-8-15-9-7-11/h2-9H,1H3,(H,17,19)(H2,16,18,20)

Upstream product

• 54-85-3 isoniazid 
• 614-69-7 2-tolyl isothiocyanate 
• 75-15-0 carbon disulfide 
• 95-53-4 o-toluidine 

Downstream Products

• 16629-41-7 5-pyridin-4-yl-4-o-tolyl-2,4-dihydro-[1,2,4]triazole-3-thione 
• 117080-42-9 2-(2-methylphenyl)amino-5-(4-pyridyl)-1,3,4-thiadiazole 
• 117080-50-9 N-(2-methylphenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-2-amine 

Relevant academic research and scientific papers

Synthesis and antitumor activity of 4-cyclohexyl/aryl-5-(pyridin-4-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones

The reaction of 2-isonicotinoyl-N-cyclohexyl/arylhydrazinecarbothioamide (2a-r) with sodium hydroxide, in each case, a single product was obtained. The structures of the compounds were confirmed on the basis of their elemental analysis and spectral data.

Synthesis and anti-Candidal activity of N-(4-aryl/cyclohexyl)-2-(pyridine- 4-yl carbonyl) hydrazinecarbothioamide

Eighteen N-(4-aryl/cyclohexyl)-2-(pyridine-4-yl carbonyl) hydrazinecarbothioamide derivatives were synthesized, evaluated against ten clinical isolates of Candida spp. and compared with itraconazole. Introduction of p-chloro (2c), p-iodo (2q), m-chloro (2

Synthesis and anticonvulsant activity of substituted oxadiazole and thiadiazole derivatives

A series of five membered heterocyclics was synthesized by the reaction between isoniazid and various substituted isothiocyanates and was tested for their anticonvulsant activity by determining their ability to provide protection against convulsions induc

Synthesis and molecular structure of new S-nucleosides of 5-(4-pyridyl)-4-aryl-4H-1,2,4-triazole-3-thiols

The synthesis of some new S-nucleosides of 5-(4-pyridyl)-4-aryl-4H-l,2,4- triazole-3-thiols (4a-n) is described. Direct glycosylation of (4a-n) with tetra-O-acetyl-α-D-glucopyranosyl bromide in the presence of potassium hydroxide followed by deacetylation using dry ammonia in methanol gave the corresponding 3-S-(β-D-glucopyranosyl)-5-(4-pyridyl)-4-aryl-4H-l,2,4- triazoles (6a-n) in good yields. All the compounds were fully characterized by means of 1H NMR, 13C NMR spectra and elemental analyses. To assist in the interpretation of the spectroscopic data, the crystal structure of 3-S-(2′,3′,4′,6′-tetra-O-acetyl-β-D- glucopyranosyl)-5-(4-pyridyl)-4-phenyl-4H-l,2,4-triazole (5a) was determined by X-ray diffraction.

Microwave-assisted rapid synthesis of thiosemicarbazide derivatives

Rapid and highly efficient synthesis of thiosemicarbazides by the coupling of isothiocyanate and carboxylic acid hydrazides in small amount of a polar solvent is achieved under microwave irradiation by using a domestic microwave oven. The reaction proceed