61025-23-8

Basic information

• Product Name: 4,4-dimethyl-2-[(E)-2-phenylethenyl]-4,5-dihydro-1,3-oxazole
• Synonyms: 4,4-Dimethyl-2-[(E)-2-phenylvinyl]-4,5-dihydro-1,3-oxazole; oxazole, 4,5-dihydro-4,4-dimethyl-2-[(E)-2-phenylethenyl]-
• CAS NO: 61025-23-8
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.2643
• Mol File: 61025-23-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 269.4°C at 760 mmHg
• Flash Point: 96.9°C
• Density: 1g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 4,4-dimethyl-2-[(E)-2-phenylethenyl]-4,5-dihydro-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-dimethyl-2-[(E)-2-phenylethenyl]-4,5-dihydro-1,3-oxazole(61025-23-8)
• EPA Substance Registry System: 4,4-dimethyl-2-[(E)-2-phenylethenyl]-4,5-dihydro-1,3-oxazole(61025-23-8)

Safety Data

• Hazardous Substances Data: 61025-23-8(Hazardous Substances Data)

Upstream product

• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 118559-32-3 4,4-dimethyl-2-(tri-n-butylstannyl)-2-oxazoline 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 100-52-7 benzaldehyde 
• 3376-24-7 (Z)-N-benzylidene-2-methylpropan-2-amine oxide 
• 74307-97-4 2-chloromethyl-4,4-dimethyl-4,5-dihydro-1,3-oxazole 
• 14371-10-9 (E)-3-phenylpropenal 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 115492-29-0 4,4-Dimethyl-2-(2-phenyl-1-phenylsulfanyl-ethyl)-4,5-dihydro-oxazole 
• 115492-23-4 5,5-dimethyl 2-phenylthiomethyl oxazoline 
• 100-39-0 benzyl bromide 
• 1772-43-6 2,4,4-trimethyl oxazoline 
• 140-10-3 (E)-3-phenylacrylic acid 
• 126437-19-2 1-cinnamoyl-2,2-dimethylaziridine 

Downstream Products

• 61025-24-9 2-(2,4-diphenyl-pent-4-enyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 132654-04-7 3-(1-Methyl-2-oxo-cyclohexyl)-3-phenyl-propionic acid 
• 61025-25-0 3,5-Diphenyl-4-hexensaeure 
• 61025-26-1 3,5-Diphenyl-4-hexen-1-ol 
• 13608-28-1 4,4-dimethyl-2-(2-phenylethyl)-4,5-dihydro-1,3-oxazole 

Relevant articles and documents

Aerobic C(sp2)-H Hydroxylations of 2-Aryloxazolines: Fast Access to Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores

The direct hydroxylation of 2-aryloxazolines via a deprotonative magnesiation using TMPMgCl·LiCl and subsequent oxidation with molecular oxygen or air as a green oxidant is reported. This method proceeds under mild conditions at room temperature with high regioselectivity and chemoselectivity. The obtained phenols exhibit tunable luminescence properties, induced by excited-state intramolecular proton transfer. This method opens a new opportunity for the sustainable synthesis of luminescent organic molecules.

Direct synthesis of 2-oxazolines from carboxylic acids using 2-chloro-4,6-dimethoxy-1,3,5-triazine under mild conditions

2-Acyloxy-4,6-dimethoxy-1,3,5-triazines obtained from carboxylic acids and 2-chloro-4,6-dimethoxy-1,3,5-triazine were subsequently treated with 2-amino-2-methyl-1-propanol to afford the corresponding 2-oxazolines in excellent yield at room temperature.

A highly stereoselective synthesis of α,β-unsaturated oxazolines

Lithiated 2,4,4-trimethyl-2-oxazoline 2a and 2-chloromethyl-4,4-dimethyl-2-oxazoline 2b react smoothly with a number of nitrones 3 to produce α,β-unsaturated oxazolines 6 and 7 highly stereoselectively.