74331-99-0Relevant articles and documents
Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy
Lian, Xizhen,Huang, Yanyan,Zhu, Yuanyuan,Fang, Yu,Zhao, Rui,Joseph, Elizabeth,Li, Jialuo,Pellois, Jean-Philippe,Zhou, Hong-Cai
, p. 5725 - 5730 (2018)
Prodrug activation, by exogenously administered enzymes, for cancer therapy is an approach to achieve better selectivity and less systemic toxicity than conventional chemotherapy. However, the short half-lives of the activating enzymes in the bloodstream has limited its success. Demonstrated here is that a tyrosinase-MOF nanoreactor activates the prodrug paracetamol in cancer cells in a long-lasting manner. By generating reactive oxygen species (ROS) and depleting glutathione (GSH), the product of the enzymatic conversion of paracetamol is toxic to drug-resistant cancer cells. Tyrosinase-MOF nanoreactors cause significant cell death in the presence of paracetamol for up to three days after being internalized by cells, while free enzymes totally lose activity in a few hours. Thus, enzyme-MOF nanocomposites are envisioned to be novel persistent platforms for various biomedical applications.
Structure Determination of the Active Sulfhydryl Reagent in Gill Tissue of the Mushroom Agaricus bisporus
Mize, Patrick D.,Jeffs, Peter W.,Boekelheide, Kim
, p. 3540 - 3543 (2007/10/02)
The red pigment found in sporulating gill tissue of the mushroom Agaricus bisporus, which is a potent inhibitor of a number of enzymes containing sulfhydryl groups at their active sites, is shown to be 2-hydroxy-4-imino-2,5-cyclohexadienone (4).
