743420-68-0Relevant academic research and scientific papers
Rapid entry into heterocycle-fused benzylic azepines and azocines via directed metallation/ring-closing metathesis
Moss, Thomas A.
, p. 4254 - 4258 (2013/07/26)
The efficient synthesis of a range of heterocycle-fused benzylic azepine and azocine derivatives is reported, employing a directed metallation/ruthenium- catalysed ring-closing metathesis approach. A base-mediated tautomerisation approach can be used to access both the azepine and azocine derivatives from the same starting material.
Iodine(III)-promoted synthesis of oxazolines from N-allylamides
Moon, Nicholas G.,Harned, Andrew M.
supporting information, p. 2960 - 2963 (2013/06/27)
PhI(OAc)2 (activated by BF3·OEt2) has been used to promote the oxidative cyclization of N-allylamides to give oxazolines. The reaction products are formed in high yield and, when a branched allylic amine is used, high diastereoselectivity. Initial mechanistic experiments suggest that the final C-O bond is formed from a reactive tight ion pair, rather than a neutral external nucleophile.
Microwave-assisted, Mo(CO)6-mediated, palladium-catalyzed amino-carbonylation of aryl halides using allylamine: from exploration to scale-up
Appukkuttan, Prasad,Axelsson, Linda,der Eycken, Erik Van,Larhed, Mats
, p. 5625 - 5628 (2008/12/22)
Palladium-catalyzed aminocarbonylations of various (hetero)aryl halides with allylamine using Mo(CO)6 as a solid, in situ CO source, were explored. Microwave-enhanced conditions proved to be highly useful in promoting the conversions in a mere 10-20 min with various (hetero)aryl iodides, bromides and chlorides. The scale-up of a microwave-enhanced aminocarbonylation to 25 mmol scale was performed successfully.
Convenient synthesis of furan-3-carboxylic acid and derivatives
Zanatta, Nilo,Faoro, Débora,Silva, Simone C.,Bonacorso, Helio G.,Martins, Marcos A.P.
, p. 5689 - 5691 (2007/10/03)
A convenient synthesis of furan-3-carboxylic acid and derivatives from aromatization of 4-trichloroacetyl-2,3-dihydrofuran followed by nucleophilic displacement of the trichloromethyl group by hydroxide, alcohols, and amines, is presented.
