74411-15-7

Basic information

• Product Name: Propanoic acid, 2-(2-chlorophenoxy)-, methyl ester
• CAS NO: 74411-15-7
• Molecular Formula: C10H11ClO3
• Molecular Weight: 214.649
• Mol File: 74411-15-7.mol

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-(2-chlorophenoxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-(2-chlorophenoxy)-, methyl ester(74411-15-7)
• EPA Substance Registry System: Propanoic acid, 2-(2-chlorophenoxy)-, methyl ester(74411-15-7)

Safety Data

• Hazardous Substances Data: 74411-15-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 76466-16-5 2-(2-chlorophenoxy)propionic acid 
• 211184-89-3 2-(2-chloro-phenoxy)-propionyl chloride 
• 5445-17-0 Methyl 2-bromopropionate 
• 95-57-8 2-monochlorophenol 
• 3046-25-1 o-chlorophenol, potassium salt 

Downstream Products

• 122674-93-5 (S)-methyl 2-(2-chlorophenoxy) propionate 
• 140146-13-0 (R)-methyl 2-(2-chlorophenoxy) propionate 
• 25140-86-7 (R)-2-(2-chlorophenoxy) propanoic acid 
• 25140-86-7 (S)-2-(2-chlorophenoxy) propanoic acid 
• 76466-16-5 2-(2-chlorophenoxy)propionic acid 

Relevant articles and documents

Might the observed α2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?

We recently reported that the α2-adrenoreceptor (AR) ligand allyphenyline (9) significantly enhanced morphine analgesia (due to its α2C-AR agonism), was devoid of sedative side effects (due to its α2A-AR antagonism), preve

Optical resolution of aryloxypropionic acids and their esters by HPLC on cellulose tris-3,5-dimethyl-triphenylcarbamate derivative

Chiral chromatographic resolution of a series of antiphlogistic 2- aryloxypropionic acids and their methyl and ethyl esters was performed using a Chiralcel OD column. The CSP selected resolved most of the acids and esters efficiently, the enantiomers being well separated without requiring time consuming analysis. Chromatographic separation of R enriched samples was performed to determine the correct elution order. Using eluting systems such as hexane and 2-propanol, or hexane, 2-propanol and formic acid, the S enantiomer of all acids and esters was always found to elute first. We also considered the role of electron-donating or electron-withdrawing substituents (at the aryloxylic moiety) on the chiral resolution. It was shown that the electronic features of the substituents have more influence on the chiral interactions between the solutes and the CSP than their steric hindrance. Finally we determined, by molecular models, the interaction between CSP and solutes. In this way were able to determine all the potential sites for interactions, which are compatible with the conformations of the compounds and the structure of the stationary phase, and point out those interactions which enable chiral resolution.

Enzyme catalysed hydrolysis of chlorophenoxypropionates

We report on the enzymatic hydrolysis of methyl 2-phenoxypropionate and of the following chlorinated derivatives: methyl o-chloro-, m-chloro-, p-chloro-, and o,p-dichloro-2-phenoxypropionates. α-Chymotripsyn, lipase, and pig liver esterase have an R enantioselectivity whereas subtilisin has an S enantioselectivity.Enantiomeric excess (e.e.) cover a wide range (from 5 to 100percent).