74476-47-4

Basic information

• Product Name: 2-CHLORO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-CHLORO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER;ethyl 2-chloro-4-phenylthiazole-5-carboxylate;ethyl 2-chloro-4-phenyl-1,3-thiazole-5-carboxylate
• CAS NO: 74476-47-4
• Molecular Formula: C₁₂H₁₀ClNO₂S
• Molecular Weight: 267.73
• Mol File: 74476-47-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER(74476-47-4)
• EPA Substance Registry System: 2-CHLORO-4-PHENYL-5-THIAZOLECARBOXYLIC ACID ETHYL ESTER(74476-47-4)

Safety Data

• Hazardous Substances Data: 74476-47-4(Hazardous Substances Data)

Upstream product

• 64399-23-1 ethyl 4-phenyl-2-aminothiazole-5-carboxylate 
• 13950-67-9 ethyl 2,3-dihydro-2-oxo-4-phenyl-5-thiazolecarboxylate 
• 53256-19-2 ethyl (Z)-3-amino-3-phenylacrylate 
• 33831-72-0 ethyl 3-amino-3-phenylprop-2-enoate 

Downstream Products

• 74476-66-7 2-chloro-4-phenyl-thiazole-5-carboxylic acid 
• 928152-30-1 ethyl 2-(4-(2-methoxyphenyl)-piperazin-1-yl)-4-phenythiazole-5-carboxylate 
• 947520-92-5 2-(benzoimidazol-1-yl)-4-phenylthiazole-5-carboxylic acid ethyl ester 
• 947520-91-4 2-(5,6-dimethoxy-benzoimidazol-1-yl)-4-phenyl-thiazole-5-carboxylic acid ethyl ester 

Relevant articles and documents

Thiazolyl-benzimidazoles

The invention is directed to compounds of formula (1) [image] and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.