74476-47-4

Upstream product

• 13950-67-9 ethyl 2,3-dihydro-2-oxo-4-phenyl-5-thiazolecarboxylate 
• 33831-72-0 ethyl 3-amino-3-phenylprop-2-enoate 
• 64399-23-1 ethyl 4-phenyl-2-aminothiazole-5-carboxylate 
• 53256-19-2 ethyl (Z)-3-amino-3-phenylacrylate 

Downstream Products

• 74476-66-7 2-chloro-4-phenyl-thiazole-5-carboxylic acid 
• 947520-92-5 2-(benzoimidazol-1-yl)-4-phenylthiazole-5-carboxylic acid ethyl ester 
• 947520-91-4 2-(5,6-dimethoxy-benzoimidazol-1-yl)-4-phenyl-thiazole-5-carboxylic acid ethyl ester 
• 928152-30-1 ethyl 2-(4-(2-methoxyphenyl)-piperazin-1-yl)-4-phenythiazole-5-carboxylate 

Relevant academic research and scientific papers

Thiazolyl-benzimidazoles

The invention is directed to compounds of formula (1) [image] and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.

THIAZOLE COMPOUNDS AND THEIR USE AS PGD2 ANTAGONISTS

A compound for use as a PGD2 antagonist is of structural formula [1] in which: A represents a fully saturated or partially unsaturated monocyclic 5-7 membered ring containing one or two nitrogen atoms; B represents a direct bond, an optionally substituted

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.

2-Substituted-4-aryl-5-thiazolecarboxylic acids and their derivatives as safening agents

These compounds have been found to be effective in reducing herbicidal injury to direct-seeded rice caused by 2-chloro-2',6'-diethyl-N-(butoxymethyl)acetanilide.