74476-54-3

Upstream product

• 74476-53-2 ethyl 2-amino-4-(4-chlorophenyl)-1,3-thiazole-5-carboxylate 
• 122-01-0 4-chloro-benzoyl chloride 
• 2881-63-2 ethyl (4-chlorobenzoyl)acetate 
• 24045-75-8 ethyl 2-chloro-3-(4-chlorophenyl)-3-oxopropanoate 

Relevant academic research and scientific papers

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.

2-Substituted-4-aryl-5-thiazolecarboxylic acids and their derivatives as safening agents

These compounds have been found to be effective in reducing herbicidal injury to direct-seeded rice caused by 2-chloro-2',6'-diethyl-N-(butoxymethyl)acetanilide.