7450-03-5Relevant articles and documents
Cobalt-Catalyzed Defluorosilylation of Aryl Fluorides via Grignard Reagent Formation
Cho, Hyungdo,Cho, Seung Hwan,Jang, Minjae,Jeong, Jongheon,Kim, Hyunseok,Lee, Eunsung,Lim, Soobin
supporting information, p. 7387 - 7392 (2020/10/12)
Transition-metal-catalyzed transformations of the carbon-fluorine bond not only tackle an interesting problem of challenging bond activation but also offer new synthetic strategies where the relatively inert C-F bond is converted to versatile functional groups. Herein we report a practical cobalt-catalyzed silylation of aryl fluorides that uses a cheap electrophilic silicon source with magnesium. This method is compatible with various silicon sources and can be operated under aerobic conditions. Mechanistic studies support the in situ formation of a Grignard reagent, which is captured by the electrophilic silicon source.
Cationic Chiral Fluorinated Oxazaborolidines. More Potent, Second-Generation Catalysts for Highly Enantioselective Cycloaddition Reactions
Mahender Reddy, Karla,Bhimireddy, Eswar,Thirupathi, Barla,Breitler, Simon,Yu, Shunming,Corey
, p. 2443 - 2453 (2016/03/08)
The coordination of chiral ligands to Lewis acid metal derivatives, a useful strategy for enantioselective, electrophilic catalysis, generally leads to a lower level of catalytic activity than that of the original uncomplexed compound. Activation by furth
Palladium-catalyzed direct CH bond arylation of simple arenes with aryltrimethylsilanes
Funaki, Kenji,Kawai, Hiroshi,Sato, Tetsuo,Oi, Shuichi
supporting information; experimental part, p. 1050 - 1052 (2011/12/05)
Direct CH bond arylation of arenes with aryltrimethylsilanes catalyzed by PdCl2 in the presence of CuCl2 as an oxidant has been developed. In addition to the role as the oxidant, CuCl2 is found to be necessary for the selective crosscoupling reaction.
