74502-83-3

Usage

Uses

Used in Chemical Synthesis:
2-(Chloromethyl)-4,6-dimethylpyrimidine is used as a key intermediate in the synthesis of various chemical compounds. Its unique structure allows it to be a versatile building block in the creation of complex molecules, particularly in the fields of pharmaceuticals and materials science.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(Chloromethyl)-4,6-dimethylpyrimidine is used as a precursor for the development of new drugs. Its reactivity and structural features make it a valuable component in the synthesis of potential therapeutic agents, contributing to the advancement of medicine.
Used in Materials Science:
2-(Chloromethyl)-4,6-dimethylpyrimidine is also utilized in materials science for the development of novel materials with specific properties. Its incorporation into polymers and other materials can lead to the creation of materials with improved characteristics, such as enhanced stability or specific reactivity, which can be applied in various industries.

InChI:InChI=1/C7H9ClN2/c1-5-3-6(2)10-7(4-8)9-5/h3H,4H2,1-2H3

Upstream product

• 56536-48-2 2,4,6-trimethylpyrimidine 1-oxide 
• 89966-68-7 2,6-dimethyl-4-dimethylaminopyrimidine 1-oxide 
• 54198-72-0 (4,6-dimethylpyrimidin-2-yl)methanol 
• 17759-15-8 4-methoxy-2,6-dimethylpyrimidine 1-oxide 
• 27427-89-0 methyl 4,6-dimethylpyrimidine-2-carboxylate 
• 4472-44-0 2-chloro-4,6-dimethylpyrimidine 
• 1558-17-4 4,6-dimethylpyrimidine 

Downstream Products

• 32691-58-0 2-(cyanomethylene)-4,6-dimethylpyrimidine 
• 126230-97-5 5,7-Dihydro-2-methylfuro<3,4-b>pyridine 
• 1351764-56-1 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-((4,6-dimethylpyrimidin-2-yl)methoxy)-5-fluoronicotinamide 
• 54198-72-0 (4,6-dimethylpyrimidin-2-yl)methanol 
• 77204-31-0 4,6-dimethyl-2-trans-styrylpyrimidine 
• 77204-39-8 2-Benzyl-2-(4,6-dimethyl-pyrimidin-2-yl)-3-phenyl-propionitrile 
• 77204-23-0 α-(4,6-dimethyl-2-pyrimidinyl)cinnamonitrile 
• 77204-33-2 2-cyclohexylidenemethyl-4,6-dimethylpyrimidine 
• 27427-90-3 4,6-dimethyl-2-pyrimidinecarboxaldehyde 
• 77204-30-9 (4,6-dimethyl-2-pyrimidinylmethyl)triphenylphosphonium chloride 

Relevant academic research and scientific papers

IMIDAZOTRIAZINONE COMPOUNDS

The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

Studies on Pyrimidine Derivatives. XXXII. Reaction of 4-Substituted 2,6-Dimethylpyrimidine 1-Oxides with Phosphoryl Chloride

The reaction of 2,6-dimethyl-4-phenylpyrimidine 1-oxide with phosphoryl chloride gave 4-chloromethyl-2-methyl-6-phenylpyrimidine exclusively.In contrast, 2,6-dimethyl-4-methoxy-pyrimidine 1-oxide and 2,6-dimethyl-4-dimethylaminopyrimidine 1-oxide reacted with the same reagent to give the corresponding 2-chloromethylpyrimidines predominantly.Keywords - pyrimidine N-oxide; chloromethylpyrimidine; phosphoryl chloride; siteselective reaction; substituent effect

Studies on Pyrimidine Derivatives. XX. Synthetic Utility of Hydroxymethylpyrimidines and Related Compounds

The conversion of a hydroxymethyl group at the 2- or 4-position of simple pyrimidines to a chloromethyl, cyanomethyl, ethoxycarbonylmethyl, or formyl group is described.Various pyrimidines having an olefinic side chain were also synthesized via Witting reagents derived from chloromethylpyrimidines.Keywords - hydroxymethylation; chloromethylpyrimidine; cyanomethylpyrimidine; pyrimidinecarbaldehyde; Witting reaction